| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL55523.1 | CBL56474.1 | PFREUD_00220 | PFREUD_09480 | Hypothetical membrane protein. | 5.2 Protein of unknown function similar to proteins from other organisms. | 0.723 |
| CBL55523.1 | CBL56794.1 | PFREUD_00220 | PFREUD_12780 | Hypothetical membrane protein. | 5.2 Protein of unknown function similar to proteins from other organisms. | 0.503 |
| CBL55523.1 | iclR | PFREUD_00220 | PFREUD_13290 | Hypothetical membrane protein. | This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. | 0.539 |
| CBL56474.1 | CBL55523.1 | PFREUD_09480 | PFREUD_00220 | 5.2 Protein of unknown function similar to proteins from other organisms. | Hypothetical membrane protein. | 0.723 |
| CBL56474.1 | iclR | PFREUD_09480 | PFREUD_13290 | 5.2 Protein of unknown function similar to proteins from other organisms. | This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. | 0.692 |
| CBL56794.1 | CBL55523.1 | PFREUD_12780 | PFREUD_00220 | 5.2 Protein of unknown function similar to proteins from other organisms. | Hypothetical membrane protein. | 0.503 |
| CBL56794.1 | iclR | PFREUD_12780 | PFREUD_13290 | 5.2 Protein of unknown function similar to proteins from other organisms. | This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. | 0.602 |
| ackA | hemB | PFREUD_00690 | PFREUD_18910 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | Delta-aminolevulinic acid dehydratase (Porphobilinogen synthase); Porphyrin biosynthese. 2 5-aminolevulinate = porphobilinogen + 2 H2O cofactor : zinc; Belongs to the ALAD family. | 0.643 |
| ackA | hemC | PFREUD_00690 | PFREUD_18960 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.663 |
| ackA | hemL2 | PFREUD_00690 | PFREUD_19260 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (Glutamate-1-semialdehyde aminotransferase)(GSA-AT); 5-Aminolevulinate <=> (S)-4-Amino-5-oxopentanoate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.425 |
| ackA | iclR | PFREUD_00690 | PFREUD_13290 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. | 0.709 |
| ackA | pta | PFREUD_00690 | PFREUD_00700 | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | Acetyl-CoA + Orthophosphate <=> CoA + Acetyl phosphate / Propanoyl-CoA + Orthophosphate <=> Propanoyl phosphate + CoA. | 0.999 |
| hemB | ackA | PFREUD_18910 | PFREUD_00690 | Delta-aminolevulinic acid dehydratase (Porphobilinogen synthase); Porphyrin biosynthese. 2 5-aminolevulinate = porphobilinogen + 2 H2O cofactor : zinc; Belongs to the ALAD family. | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | 0.643 |
| hemB | hemC | PFREUD_18910 | PFREUD_18960 | Delta-aminolevulinic acid dehydratase (Porphobilinogen synthase); Porphyrin biosynthese. 2 5-aminolevulinate = porphobilinogen + 2 H2O cofactor : zinc; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
| hemB | hemL2 | PFREUD_18910 | PFREUD_19260 | Delta-aminolevulinic acid dehydratase (Porphobilinogen synthase); Porphyrin biosynthese. 2 5-aminolevulinate = porphobilinogen + 2 H2O cofactor : zinc; Belongs to the ALAD family. | Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (Glutamate-1-semialdehyde aminotransferase)(GSA-AT); 5-Aminolevulinate <=> (S)-4-Amino-5-oxopentanoate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.997 |
| hemB | iclR | PFREUD_18910 | PFREUD_13290 | Delta-aminolevulinic acid dehydratase (Porphobilinogen synthase); Porphyrin biosynthese. 2 5-aminolevulinate = porphobilinogen + 2 H2O cofactor : zinc; Belongs to the ALAD family. | This family of bacterial transcriptional regulators includes the glycerol operon regulatory protein and acetate operon repressor both of which are members of the iclR family. | 0.659 |
| hemB | pta | PFREUD_18910 | PFREUD_00700 | Delta-aminolevulinic acid dehydratase (Porphobilinogen synthase); Porphyrin biosynthese. 2 5-aminolevulinate = porphobilinogen + 2 H2O cofactor : zinc; Belongs to the ALAD family. | Acetyl-CoA + Orthophosphate <=> CoA + Acetyl phosphate / Propanoyl-CoA + Orthophosphate <=> Propanoyl phosphate + CoA. | 0.642 |
| hemC | ackA | PFREUD_18960 | PFREUD_00690 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | 0.663 |
| hemC | hemB | PFREUD_18960 | PFREUD_18910 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Delta-aminolevulinic acid dehydratase (Porphobilinogen synthase); Porphyrin biosynthese. 2 5-aminolevulinate = porphobilinogen + 2 H2O cofactor : zinc; Belongs to the ALAD family. | 0.999 |
| hemC | hemL2 | PFREUD_18960 | PFREUD_19260 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (Glutamate-1-semialdehyde aminotransferase)(GSA-AT); 5-Aminolevulinate <=> (S)-4-Amino-5-oxopentanoate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.928 |