| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL56508.1 | nadD | PFREUD_09830 | PFREUD_08530 | NUDIX protein. | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.903 |
| CBL56508.1 | nadE | PFREUD_09830 | PFREUD_22890 | NUDIX protein. | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.909 |
| CBL56508.1 | npdA | PFREUD_09830 | PFREUD_01440 | NUDIX protein. | Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | 0.907 |
| CBL56508.1 | pntA | PFREUD_09830 | PFREUD_21540 | NUDIX protein. | NAD(P)(+) transhydrogenase (AB-specific); NADPH + NAD+ <=> NADP+ + NADH. | 0.900 |
| CBL56508.1 | pntB | PFREUD_09830 | PFREUD_21530 | NUDIX protein. | NADH dehydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.900 |
| CBL56508.1 | ppnK | PFREUD_09830 | PFREUD_13670 | NUDIX protein. | Probable inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.900 |
| CBL56891.1 | ppnK | PFREUD_13740 | PFREUD_13670 | 6 Protein of unknown function, without similarity to other proteins. | Probable inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.732 |
| CBL56891.1 | pyrG | PFREUD_13740 | PFREUD_13650 | 6 Protein of unknown function, without similarity to other proteins. | CTP synthase (UTP--ammonia ligase) (CTP synthetase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.466 |
| CBL56891.1 | recN | PFREUD_13740 | PFREUD_13660 | 6 Protein of unknown function, without similarity to other proteins. | DNA repair protein; May be involved in recombinational repair of damaged DNA. | 0.643 |
| nadD | CBL56508.1 | PFREUD_08530 | PFREUD_09830 | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | NUDIX protein. | 0.903 |
| nadD | nadE | PFREUD_08530 | PFREUD_22890 | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.993 |
| nadD | npdA | PFREUD_08530 | PFREUD_01440 | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | 0.920 |
| nadD | pntA | PFREUD_08530 | PFREUD_21540 | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | NAD(P)(+) transhydrogenase (AB-specific); NADPH + NAD+ <=> NADP+ + NADH. | 0.905 |
| nadD | pntB | PFREUD_08530 | PFREUD_21530 | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | NADH dehydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.900 |
| nadD | ppnK | PFREUD_08530 | PFREUD_13670 | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Probable inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase); Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.940 |
| nadE | CBL56508.1 | PFREUD_22890 | PFREUD_09830 | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | NUDIX protein. | 0.909 |
| nadE | nadD | PFREUD_22890 | PFREUD_08530 | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Probable nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.993 |
| nadE | npdA | PFREUD_22890 | PFREUD_01440 | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | Silent information regulator protein Sir2; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | 0.937 |
| nadE | pntA | PFREUD_22890 | PFREUD_21540 | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | NAD(P)(+) transhydrogenase (AB-specific); NADPH + NAD+ <=> NADP+ + NADH. | 0.909 |
| nadE | pntB | PFREUD_22890 | PFREUD_21530 | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | NADH dehydrogenase; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.927 |