| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL56920.1 | trpB2 | PFREUD_14210 | PFREUD_14220 | 5.2 Protein of unknown function similar to proteins from other organisms. | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.779 |
| cysE | glyA | PFREUD_06550 | PFREUD_18740 | L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA. | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.872 |
| cysE | ilvA | PFREUD_06550 | PFREUD_03750 | L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.811 |
| cysE | pf3022 | PFREUD_06550 | PFREUD_11000 | L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.466 |
| cysE | sdaA | PFREUD_06550 | PFREUD_18570 | L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA. | L-serine dehydratase (L-serine ammonia-lyase); L-Serine <=> Pyruvate + NH3 / alpha-Amino acid <=> 2-Oxo acid + NH3 L-Serine <=> 2-Aminoacrylate + H2O /; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.910 |
| cysE | serB/thrH | PFREUD_06550 | PFREUD_10330 | L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA. | Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; O-Phospho-L-serine + H2O <=> L-Serine + Orthophosphate and D-O-Phosphoserine + H2O <=> D-Serine + Orthophosphate. | 0.850 |
| cysE | trpA | PFREUD_06550 | PFREUD_11880 | L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA. | Tryptophan synthase alpha chain (TrpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.810 |
| cysE | trpB | PFREUD_06550 | PFREUD_11890 | L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA. | Tryptophan synthase beta chain (TrpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.810 |
| cysE | trpB2 | PFREUD_06550 | PFREUD_14220 | L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA. | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.800 |
| glyA | cysE | PFREUD_18740 | PFREUD_06550 | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA. | 0.872 |
| glyA | ilvA | PFREUD_18740 | PFREUD_03750 | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.978 |
| glyA | pf3022 | PFREUD_18740 | PFREUD_11000 | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.821 |
| glyA | sdaA | PFREUD_18740 | PFREUD_18570 | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase (L-serine ammonia-lyase); L-Serine <=> Pyruvate + NH3 / alpha-Amino acid <=> 2-Oxo acid + NH3 L-Serine <=> 2-Aminoacrylate + H2O /; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.984 |
| glyA | serB/thrH | PFREUD_18740 | PFREUD_10330 | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; O-Phospho-L-serine + H2O <=> L-Serine + Orthophosphate and D-O-Phosphoserine + H2O <=> D-Serine + Orthophosphate. | 0.936 |
| glyA | trpA | PFREUD_18740 | PFREUD_11880 | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha chain (TrpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.950 |
| glyA | trpB | PFREUD_18740 | PFREUD_11890 | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain (TrpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.921 |
| glyA | trpB2 | PFREUD_18740 | PFREUD_14220 | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.905 |
| ilvA | cysE | PFREUD_03750 | PFREUD_06550 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | L-Serine + Acetyl-CoA <=> O-Acetyl-L-serine + CoA. | 0.811 |
| ilvA | glyA | PFREUD_03750 | PFREUD_18740 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.978 |
| ilvA | pf3022 | PFREUD_03750 | PFREUD_11000 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. | 0.832 |
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