| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL56876.1 | scpA | PFREUD_13590 | PFREUD_13600 | Transcriptional regulator; This family of conserved bacterial proteins are thought to possibly be helix-turn-helix type transcriptional regulators. | Segregation and condensation protein A; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. | 0.999 |
| CBL56876.1 | smc | PFREUD_13590 | PFREUD_14420 | Transcriptional regulator; This family of conserved bacterial proteins are thought to possibly be helix-turn-helix type transcriptional regulators. | Chromosome partition protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.943 |
| CBL56940.1 | CBL56942.1 | PFREUD_14410 | PFREUD_14430 | 6 Protein of unknown function, without similarity to other proteins. | Hypothetical membrane protein. | 0.515 |
| CBL56940.1 | ftsY | PFREUD_14410 | PFREUD_14400 | 6 Protein of unknown function, without similarity to other proteins. | Signal recognition particle receptor; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.589 |
| CBL56940.1 | mutM3 | PFREUD_14410 | PFREUD_14440 | 6 Protein of unknown function, without similarity to other proteins. | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.470 |
| CBL56940.1 | rnc | PFREUD_14410 | PFREUD_14460 | 6 Protein of unknown function, without similarity to other proteins. | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | 0.470 |
| CBL56940.1 | smc | PFREUD_14410 | PFREUD_14420 | 6 Protein of unknown function, without similarity to other proteins. | Chromosome partition protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.599 |
| CBL56942.1 | CBL56940.1 | PFREUD_14430 | PFREUD_14410 | Hypothetical membrane protein. | 6 Protein of unknown function, without similarity to other proteins. | 0.515 |
| CBL56942.1 | ftsY | PFREUD_14430 | PFREUD_14400 | Hypothetical membrane protein. | Signal recognition particle receptor; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.432 |
| CBL56942.1 | mutM3 | PFREUD_14430 | PFREUD_14440 | Hypothetical membrane protein. | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.797 |
| CBL56942.1 | rnc | PFREUD_14430 | PFREUD_14460 | Hypothetical membrane protein. | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | 0.797 |
| CBL56942.1 | smc | PFREUD_14430 | PFREUD_14420 | Hypothetical membrane protein. | Chromosome partition protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.778 |
| ffh | ftsY | PFREUD_14390 | PFREUD_14400 | GTP binding signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Signal recognition particle receptor; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 0.999 |
| ffh | mutM3 | PFREUD_14390 | PFREUD_14440 | GTP binding signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.446 |
| ffh | rnc | PFREUD_14390 | PFREUD_14460 | GTP binding signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | 0.561 |
| ffh | smc | PFREUD_14390 | PFREUD_14420 | GTP binding signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | Chromosome partition protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. | 0.567 |
| ffh | topA | PFREUD_14390 | PFREUD_20560 | GTP binding signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.466 |
| ftsY | CBL56940.1 | PFREUD_14400 | PFREUD_14410 | Signal recognition particle receptor; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | 6 Protein of unknown function, without similarity to other proteins. | 0.589 |
| ftsY | CBL56942.1 | PFREUD_14400 | PFREUD_14430 | Signal recognition particle receptor; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | Hypothetical membrane protein. | 0.432 |
| ftsY | ffh | PFREUD_14400 | PFREUD_14390 | Signal recognition particle receptor; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). | GTP binding signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.999 |