STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdhBDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; Succinyl-CoA + Enzyme N6-(dihydrolipoyl)lysine <=> CoA + [Dihydrolipoyllysine-residue succinyltransferase]S-succinyldihydrolipoyllysine, Glutaryl-CoA + Dihydrolipoamide <=> CoA + S-Glutaryldihydrolipoamide. (589 aa)    
Predicted Functional Partners:
odhA
2-oxoglutarate dehydrogenase, E1 and E2 components; Annotated from high similarity with Swiss-Prot entry Q8NRC3, a bifunctional enzyme of Corynebacterium glutamicum with E1 and E2 activity. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
 
0.997
bkdA1
Pyruvate dehydrogenase E1 component alpha subunit; Similar to Swiss-Prot entries Q9I1M2 and P09060.
 
 0.996
lpd
In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12, and catalyses oxidation of its dihydrolipoyl groups. It plays a similar role in the oxoglutarate and 3-methyl-2-oxobutanoate dehydrogenase complexes. Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine.
 0.996
bkdA2
2-oxoisovalerate dehydrogenase subunit beta Pyruvate dehydrogenase E1 component subunit beta; 44% identity with Swiss-Prot entry P09061.
 
 0.987
aceE
Dehydrogenase E1 component (2-oxo-acid dehydrogenase E1 subunit, homodimeric type); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.982
CBL56066.1
Pyruvate flavodoxin/ferredoxin oxidoreductase.
     
 0.921
lpdB
In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12, and catalyses oxidation of its dihydrolipoyl groups. It plays a similar role in the oxoglutarate and 3-methyl-2-oxobutanoate dehydrogenase complexes Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH.
 0.920
cat
Coenzyme A transferase (Putative succinyl-CoA or butyryl-CoA:coenzyme A transferase); acyl-CoA + acetate = a fatty acid anion + acetyl-CoA OR: succinate + acetyl-CoA = succinyl-CoA + acetate OR (in Pf): succinate + propionyl-CoA = succinyl-CoA + propionate.
   
  0.912
CBL56065.1
Thiamine pyrophosphate (TPP family).
   
 
 0.902
CBL57498.1
Pyridine nucleotide-disulphide oxidoreductase.
 0.853
Your Current Organism:
Propionibacterium freudenreichii
NCBI taxonomy Id: 754252
Other names: P. freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii ATCC 9614, Propionibacterium freudenreichii subsp. shermanii CIP 103027, Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii str. CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii strain CIRM-BIA1
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