| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL57085.1 | glxK/garK | PFREUD_15870 | PFREUD_16490 | 6 Protein of unknown function, without similarity to other proteins. | Glycerate kinase GlxK/GarK; ATP + D-Glycerate <=> ADP + 3-Phospho-D-glycerate; Belongs to the glycerate kinase type-1 family. | 0.932 |
| CBL57085.1 | gya | PFREUD_15870 | PFREUD_16290 | 6 Protein of unknown function, without similarity to other proteins. | Glycolate + NAD+ = glyoxylate + NADH. _ Glycolate + NAD+ <=> Glyoxylate + NADH + H+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.904 |
| CBL57808.1 | gya | PFREUD_22980 | PFREUD_16290 | Hydroxypyruvate <=> 2-Hydroxy-3-oxopropanoate; Belongs to the hyi family. | Glycolate + NAD+ = glyoxylate + NADH. _ Glycolate + NAD+ <=> Glyoxylate + NADH + H+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.905 |
| eda, | gya | PFREUD_04270 | PFREUD_16290 | 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase. | Glycolate + NAD+ = glyoxylate + NADH. _ Glycolate + NAD+ <=> Glyoxylate + NADH + H+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.905 |
| ftsI | ftsZ | PFREUD_15560 | PFREUD_15470 | Cell division protein FtsI (penicillin-binding protein 2) (Peptidoglycan glycosyltransferase); Transpeptidase activity involved in the biosynthesis of septal peptidoglycan. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.954 |
| ftsI | gya | PFREUD_15560 | PFREUD_16290 | Cell division protein FtsI (penicillin-binding protein 2) (Peptidoglycan glycosyltransferase); Transpeptidase activity involved in the biosynthesis of septal peptidoglycan. | Glycolate + NAD+ = glyoxylate + NADH. _ Glycolate + NAD+ <=> Glyoxylate + NADH + H+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.673 |
| ftsI | gyrB2 | PFREUD_15560 | PFREUD_00150 | Cell division protein FtsI (penicillin-binding protein 2) (Peptidoglycan glycosyltransferase); Transpeptidase activity involved in the biosynthesis of septal peptidoglycan. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.671 |
| ftsI | mihF | PFREUD_15560 | PFREUD_11440 | Cell division protein FtsI (penicillin-binding protein 2) (Peptidoglycan glycosyltransferase); Transpeptidase activity involved in the biosynthesis of septal peptidoglycan. | Integration host factor MihF. | 0.673 |
| ftsI | rpoB | PFREUD_15560 | PFREUD_05600 | Cell division protein FtsI (penicillin-binding protein 2) (Peptidoglycan glycosyltransferase); Transpeptidase activity involved in the biosynthesis of septal peptidoglycan. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.512 |
| ftsI | whiA | PFREUD_15560 | PFREUD_15170 | Cell division protein FtsI (penicillin-binding protein 2) (Peptidoglycan glycosyltransferase); Transpeptidase activity involved in the biosynthesis of septal peptidoglycan. | ABC transporter precursor; Involved in cell division and chromosome segregation. | 0.804 |
| ftsZ | ftsI | PFREUD_15470 | PFREUD_15560 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Cell division protein FtsI (penicillin-binding protein 2) (Peptidoglycan glycosyltransferase); Transpeptidase activity involved in the biosynthesis of septal peptidoglycan. | 0.954 |
| ftsZ | gya | PFREUD_15470 | PFREUD_16290 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Glycolate + NAD+ = glyoxylate + NADH. _ Glycolate + NAD+ <=> Glyoxylate + NADH + H+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.672 |
| ftsZ | gyrB2 | PFREUD_15470 | PFREUD_00150 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.923 |
| ftsZ | mihF | PFREUD_15470 | PFREUD_11440 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Integration host factor MihF. | 0.673 |
| ftsZ | rpoB | PFREUD_15470 | PFREUD_05600 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.822 |
| ftsZ | whiA | PFREUD_15470 | PFREUD_15170 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | ABC transporter precursor; Involved in cell division and chromosome segregation. | 0.914 |
| glxK/garK | CBL57085.1 | PFREUD_16490 | PFREUD_15870 | Glycerate kinase GlxK/GarK; ATP + D-Glycerate <=> ADP + 3-Phospho-D-glycerate; Belongs to the glycerate kinase type-1 family. | 6 Protein of unknown function, without similarity to other proteins. | 0.932 |
| glxK/garK | gya | PFREUD_16490 | PFREUD_16290 | Glycerate kinase GlxK/GarK; ATP + D-Glycerate <=> ADP + 3-Phospho-D-glycerate; Belongs to the glycerate kinase type-1 family. | Glycolate + NAD+ = glyoxylate + NADH. _ Glycolate + NAD+ <=> Glyoxylate + NADH + H+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.909 |
| gya | CBL57085.1 | PFREUD_16290 | PFREUD_15870 | Glycolate + NAD+ = glyoxylate + NADH. _ Glycolate + NAD+ <=> Glyoxylate + NADH + H+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 6 Protein of unknown function, without similarity to other proteins. | 0.904 |
| gya | CBL57808.1 | PFREUD_16290 | PFREUD_22980 | Glycolate + NAD+ = glyoxylate + NADH. _ Glycolate + NAD+ <=> Glyoxylate + NADH + H+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Hydroxypyruvate <=> 2-Hydroxy-3-oxopropanoate; Belongs to the hyi family. | 0.905 |