| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL57066.1 | idsA | PFREUD_15680 | PFREUD_05300 | Farnesyltranstransferase / Geranylgeranyl pyrophosphate synthase; Trans,trans-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranylgeranyl diphosphate Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; Belongs to the FPP/GGPP synthase family. | Heptaprenyl diphosphate synthase component II; all-trans-Hexaprenyl diphosphate + Isopentenyl diphosphate <=> all-trans-Heptaprenyl diphosphate + Pyrophosphate; Belongs to the FPP/GGPP synthase family. | 0.924 |
| CBL57066.1 | ispH | PFREUD_15680 | PFREUD_16970 | Farnesyltranstransferase / Geranylgeranyl pyrophosphate synthase; Trans,trans-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranylgeranyl diphosphate Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; Belongs to the FPP/GGPP synthase family. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.944 |
| CBL57066.1 | uppS | PFREUD_15680 | PFREUD_17010 | Farnesyltranstransferase / Geranylgeranyl pyrophosphate synthase; Trans,trans-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranylgeranyl diphosphate Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; Belongs to the FPP/GGPP synthase family. | Undecaprenyl pyrophosphate synthase (di-trans,poly-cis-decaprenylcistransferase); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.974 |
| CBL57211.1 | uppS | PFREUD_17000 | PFREUD_17010 | Hypothetical membrane protein. | Undecaprenyl pyrophosphate synthase (di-trans,poly-cis-decaprenylcistransferase); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.610 |
| cdsA | dxr | PFREUD_14740 | PFREUD_14720 | CTP + Phosphatidate <=> Pyrophosphate + CDP-diacylglycerol; Belongs to the CDS family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.873 |
| cdsA | frr | PFREUD_14740 | PFREUD_14750 | CTP + Phosphatidate <=> Pyrophosphate + CDP-diacylglycerol; Belongs to the CDS family. | Ribosome recycling factor (Ribosome-releasing factor) (RRF); Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 0.905 |
| cdsA | proS | PFREUD_14740 | PFREUD_14690 | CTP + Phosphatidate <=> Pyrophosphate + CDP-diacylglycerol; Belongs to the CDS family. | Prolyl-tRNA synthetase (Proline--tRNA ligase) (ProRS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttra [...] | 0.428 |
| cdsA | ribF | PFREUD_14740 | PFREUD_14590 | CTP + Phosphatidate <=> Pyrophosphate + CDP-diacylglycerol; Belongs to the CDS family. | Riboflavin biosynthesis protein (Riboflavin kinase) FAD synthetase; ATP + FMN <=> Pyrophosphate + FAD / ATP + Riboflavin <=> ADP + FMN; Belongs to the ribF family. | 0.628 |
| cdsA | uppS | PFREUD_14740 | PFREUD_17010 | CTP + Phosphatidate <=> Pyrophosphate + CDP-diacylglycerol; Belongs to the CDS family. | Undecaprenyl pyrophosphate synthase (di-trans,poly-cis-decaprenylcistransferase); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.771 |
| dxr | cdsA | PFREUD_14720 | PFREUD_14740 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | CTP + Phosphatidate <=> Pyrophosphate + CDP-diacylglycerol; Belongs to the CDS family. | 0.873 |
| dxr | frr | PFREUD_14720 | PFREUD_14750 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Ribosome recycling factor (Ribosome-releasing factor) (RRF); Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 0.759 |
| dxr | ispH | PFREUD_14720 | PFREUD_16970 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.975 |
| dxr | proS | PFREUD_14720 | PFREUD_14690 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Prolyl-tRNA synthetase (Proline--tRNA ligase) (ProRS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttra [...] | 0.629 |
| dxr | uppS | PFREUD_14720 | PFREUD_17010 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Undecaprenyl pyrophosphate synthase (di-trans,poly-cis-decaprenylcistransferase); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.770 |
| frr | cdsA | PFREUD_14750 | PFREUD_14740 | Ribosome recycling factor (Ribosome-releasing factor) (RRF); Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | CTP + Phosphatidate <=> Pyrophosphate + CDP-diacylglycerol; Belongs to the CDS family. | 0.905 |
| frr | dxr | PFREUD_14750 | PFREUD_14720 | Ribosome recycling factor (Ribosome-releasing factor) (RRF); Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.759 |
| frr | pheT | PFREUD_14750 | PFREUD_14010 | Ribosome recycling factor (Ribosome-releasing factor) (RRF); Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | Phenylalanyl-tRNA synthetase beta chain (Phenylalanine--tRNA ligase beta chain) (PheRS); ATP + L-Phenylalanine + tRNA(Phe) <=> AMP + Pyrophosphate + L-Phenylalanyl-tRNA(Phe); Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.827 |
| frr | proS | PFREUD_14750 | PFREUD_14690 | Ribosome recycling factor (Ribosome-releasing factor) (RRF); Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | Prolyl-tRNA synthetase (Proline--tRNA ligase) (ProRS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttra [...] | 0.547 |
| frr | uppS | PFREUD_14750 | PFREUD_17010 | Ribosome recycling factor (Ribosome-releasing factor) (RRF); Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. | Undecaprenyl pyrophosphate synthase (di-trans,poly-cis-decaprenylcistransferase); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.681 |
| idsA | CBL57066.1 | PFREUD_05300 | PFREUD_15680 | Heptaprenyl diphosphate synthase component II; all-trans-Hexaprenyl diphosphate + Isopentenyl diphosphate <=> all-trans-Heptaprenyl diphosphate + Pyrophosphate; Belongs to the FPP/GGPP synthase family. | Farnesyltranstransferase / Geranylgeranyl pyrophosphate synthase; Trans,trans-farnesyl diphosphate + isopentenyl diphosphate <=> diphosphate + geranylgeranyl diphosphate Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; Belongs to the FPP/GGPP synthase family. | 0.924 |
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