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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mmdAMethylmalonyl-CoA carboxytransferase 12S subunit (EC2.1.3.1) (Transcarboxylase 12S subunit). 610 bp; Operon (5S +12S +1.3S). Expressed in the presence of substrate. Overexpressed in response to stress. (524 aa)    
Predicted Functional Partners:
accA
ATP + acetyl-CoA + HCO(3)(-) <=> ADP + phosphate + malonyl-CoA.
 
 0.998
bccp
Methylmalonyl-CoA carboxytransferase, 1.3S subunit (Transcarboxylase, 1.3S subunit). 123bp; Operon (5S +12S +1.3S). Expressed in the presence of substrate. Overexpressed in response to stress.
 
 0.996
CBL57377.1
6 Protein of unknown function, without similarity to other proteins.
    
 0.985
CBL57379.1
Methylmalonyl-CoA carboxytransferase 5S subunit. (transcarboxylase 5S) 505 bp; Operon transcarboxylase (5S + 12S +1.3S) The 5S subunit specifically catalyzes the transfer of the carboxyl group from biotin of the 1.3S subunit to pyruvate to form oxaloacetate and 1.3S biotin. Expressed in the presence of substrate. Overexpressed in response to stress.
    
 0.982
mmgA
2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA and Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.954
CBL56582.1
Methylmalonyl-CoA epimerase; (R)-2-Methyl-3-oxopropanoyl-CoA <=> (S)-2-Methyl-3-oxopropanoyl-CoA.
 
 
 0.910
iolA
iolA (Myo-inositol catabolism IolA protein) (Methylmalonic acid semialdehyde dehydrogenase); * 3-Oxopropanoate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+.
   
  0.906
nifJ2
Pyruvate:ferredoxin (Flavodoxin) oxidoreductase.
  
 
 0.875
leuA1
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 0.874
leuA2
(2S)-2-Isopropylmalate + CoA <=> Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 0.874
Your Current Organism:
Propionibacterium freudenreichii
NCBI taxonomy Id: 754252
Other names: P. freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii ATCC 9614, Propionibacterium freudenreichii subsp. shermanii CIP 103027, Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii str. CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii strain CIRM-BIA1
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