| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBL57464.1 | mesJ | PFREUD_19720 | PFREUD_19710 | 6 Protein of unknown function, without similarity to other proteins. | CMP/dCMP deaminase, zinc-binding; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.811 |
| CBL57464.1 | upp | PFREUD_19720 | PFREUD_19730 | 6 Protein of unknown function, without similarity to other proteins. | Uracil phosphoribosyltransferase (UMP pyrophosphorylase) (UPRTase); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.638 |
| CBL57514.1 | guaA | PFREUD_20210 | PFREUD_06680 | Cobalt ABC transporter; Chorismate + NH3 <=> Anthranilate + Pyruvate + H2O. | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | 0.420 |
| CBL57514.1 | upp | PFREUD_20210 | PFREUD_19730 | Cobalt ABC transporter; Chorismate + NH3 <=> Anthranilate + Pyruvate + H2O. | Uracil phosphoribosyltransferase (UMP pyrophosphorylase) (UPRTase); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.791 |
| glyA | guaA | PFREUD_18740 | PFREUD_06680 | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | 0.767 |
| glyA | pyrB | PFREUD_18740 | PFREUD_17440 | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Carbamoyl phosphate + L-Aspartate <=> Orthophosphate + N-Carbamoyl-L-aspartate; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. | 0.497 |
| glyA | pyrF | PFREUD_18740 | PFREUD_11450 | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Orotidine 5-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Orotidine 5 prime-phosphate <=> UMP + CO2. | 0.757 |
| glyA | rpiB1 | PFREUD_18740 | PFREUD_22870 | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Ribose-5-phosphate isomerase 1. | 0.904 |
| glyA | upp | PFREUD_18740 | PFREUD_19730 | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uracil phosphoribosyltransferase (UMP pyrophosphorylase) (UPRTase); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.695 |
| guaA | CBL57514.1 | PFREUD_06680 | PFREUD_20210 | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | Cobalt ABC transporter; Chorismate + NH3 <=> Anthranilate + Pyruvate + H2O. | 0.420 |
| guaA | glyA | PFREUD_06680 | PFREUD_18740 | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | Glycine hydroxymethyltransferase precursor; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.767 |
| guaA | mesJ | PFREUD_06680 | PFREUD_19710 | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | CMP/dCMP deaminase, zinc-binding; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.710 |
| guaA | pyrB | PFREUD_06680 | PFREUD_17440 | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | Carbamoyl phosphate + L-Aspartate <=> Orthophosphate + N-Carbamoyl-L-aspartate; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. | 0.788 |
| guaA | pyrF | PFREUD_06680 | PFREUD_11450 | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | Orotidine 5-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Orotidine 5 prime-phosphate <=> UMP + CO2. | 0.781 |
| guaA | pyrH | PFREUD_06680 | PFREUD_14760 | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | Uridylate kinase PyrH; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.791 |
| guaA | upp | PFREUD_06680 | PFREUD_19730 | GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | Uracil phosphoribosyltransferase (UMP pyrophosphorylase) (UPRTase); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.607 |
| maf | pyrF | PFREUD_07150 | PFREUD_11450 | Maf-like protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Orotidine 5-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Orotidine 5 prime-phosphate <=> UMP + CO2. | 0.900 |
| maf | pyrH | PFREUD_07150 | PFREUD_14760 | Maf-like protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Uridylate kinase PyrH; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.900 |
| maf | upp | PFREUD_07150 | PFREUD_19730 | Maf-like protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Uracil phosphoribosyltransferase (UMP pyrophosphorylase) (UPRTase); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.911 |
| mesJ | CBL57464.1 | PFREUD_19710 | PFREUD_19720 | CMP/dCMP deaminase, zinc-binding; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 6 Protein of unknown function, without similarity to other proteins. | 0.811 |
