| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| clpC | clpP1 | PFREUD_20250 | PFREUD_08240 | Chaperone clpC (Clp-family ATP-binding protease) (ATP-dependent Clp protease ATP-binding subunit); Belongs to the clpA/clpB family. ClpC subfamily. The protein has been identified by proteomics as a 99 kDa protein induced by heat.Several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins. | ATP-dependent Clp protease proteolytic subunit 1 (Endopeptidase Clp 1); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.875 |
| clpC | clpP2 | PFREUD_20250 | PFREUD_08250 | Chaperone clpC (Clp-family ATP-binding protease) (ATP-dependent Clp protease ATP-binding subunit); Belongs to the clpA/clpB family. ClpC subfamily. The protein has been identified by proteomics as a 99 kDa protein induced by heat.Several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins. | ATP-dependent Clp protease proteolytic subunit 2 (Endopeptidase Clp 2); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.874 |
| clpC | dnaJ1 | PFREUD_20250 | PFREUD_17820 | Chaperone clpC (Clp-family ATP-binding protease) (ATP-dependent Clp protease ATP-binding subunit); Belongs to the clpA/clpB family. ClpC subfamily. The protein has been identified by proteomics as a 99 kDa protein induced by heat.Several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins. | Chaperone protein dnaJ 1 (DnaJ1 protein) (Heat shock protein 40 1); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds o [...] | 0.809 |
| clpC | dnaJ2 | PFREUD_20250 | PFREUD_04650 | Chaperone clpC (Clp-family ATP-binding protease) (ATP-dependent Clp protease ATP-binding subunit); Belongs to the clpA/clpB family. ClpC subfamily. The protein has been identified by proteomics as a 99 kDa protein induced by heat.Several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins. | Chaperone protein dnaJ 2 (DnaJ2 protein) (Heat shock protein 40 2); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds o [...] | 0.750 |
| clpC | dnaK1 | PFREUD_20250 | PFREUD_17840 | Chaperone clpC (Clp-family ATP-binding protease) (ATP-dependent Clp protease ATP-binding subunit); Belongs to the clpA/clpB family. ClpC subfamily. The protein has been identified by proteomics as a 99 kDa protein induced by heat.Several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins. | Chaperone protein dnaK 1 (Heat shock protein 70 1) (Heat shock 70 kDa protein 1) (HSP70 1); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.918 |
| clpC | dnaK2 | PFREUD_20250 | PFREUD_04630 | Chaperone clpC (Clp-family ATP-binding protease) (ATP-dependent Clp protease ATP-binding subunit); Belongs to the clpA/clpB family. ClpC subfamily. The protein has been identified by proteomics as a 99 kDa protein induced by heat.Several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins. | Chaperone protein dnaK 2 (Heat shock protein 70 2) (Heat shock 70 kDa protein 2) (HSP70 2); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.918 |
| clpC | grpE1 | PFREUD_20250 | PFREUD_17830 | Chaperone clpC (Clp-family ATP-binding protease) (ATP-dependent Clp protease ATP-binding subunit); Belongs to the clpA/clpB family. ClpC subfamily. The protein has been identified by proteomics as a 99 kDa protein induced by heat.Several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins. | Protein GrpE 1 (HSP-70 cofactor 1) (Co-chaperone protein GrpE1); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing th [...] | 0.845 |
| clpC | grpE2 | PFREUD_20250 | PFREUD_04640 | Chaperone clpC (Clp-family ATP-binding protease) (ATP-dependent Clp protease ATP-binding subunit); Belongs to the clpA/clpB family. ClpC subfamily. The protein has been identified by proteomics as a 99 kDa protein induced by heat.Several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins. | Protein GrpE 2 (HSP-70 cofactor 2) (Co-chaperone protein GrpE2); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing th [...] | 0.819 |
| clpC | hsp20 | PFREUD_20250 | PFREUD_09500 | Chaperone clpC (Clp-family ATP-binding protease) (ATP-dependent Clp protease ATP-binding subunit); Belongs to the clpA/clpB family. ClpC subfamily. The protein has been identified by proteomics as a 99 kDa protein induced by heat.Several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins. | Belongs to the small heat shock protein (HSP20) family.These seem to act as chaperones that can protect other proteins against heat-induced denaturation and aggregation. Hsp20 proteins seem to form large heterooligomeric aggregates. Structurally, this family is characterized by the presence of a conserved C-terminal domain of about 100 residues. | 0.850 |
| clpC | hsp20-3 | PFREUD_20250 | PFREUD_22790 | Chaperone clpC (Clp-family ATP-binding protease) (ATP-dependent Clp protease ATP-binding subunit); Belongs to the clpA/clpB family. ClpC subfamily. The protein has been identified by proteomics as a 99 kDa protein induced by heat.Several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins. | Belongs to the small heat shock protein (HSP20) family.These seem to act as chaperones that can protect other proteins against heat-induced denaturation and aggregation. Hsp20 proteins seem to form large heterooligomeric aggregates. Structurally, this family is characterized by the presence of a conserved C-terminal domain of about 100 residues. | 0.821 |
| clpP1 | clpC | PFREUD_08240 | PFREUD_20250 | ATP-dependent Clp protease proteolytic subunit 1 (Endopeptidase Clp 1); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone clpC (Clp-family ATP-binding protease) (ATP-dependent Clp protease ATP-binding subunit); Belongs to the clpA/clpB family. ClpC subfamily. The protein has been identified by proteomics as a 99 kDa protein induced by heat.Several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins. | 0.875 |
| clpP1 | clpP2 | PFREUD_08240 | PFREUD_08250 | ATP-dependent Clp protease proteolytic subunit 1 (Endopeptidase Clp 1); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease proteolytic subunit 2 (Endopeptidase Clp 2); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.998 |
| clpP1 | dnaJ1 | PFREUD_08240 | PFREUD_17820 | ATP-dependent Clp protease proteolytic subunit 1 (Endopeptidase Clp 1); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein dnaJ 1 (DnaJ1 protein) (Heat shock protein 40 1); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds o [...] | 0.446 |
| clpP1 | dnaJ2 | PFREUD_08240 | PFREUD_04650 | ATP-dependent Clp protease proteolytic subunit 1 (Endopeptidase Clp 1); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein dnaJ 2 (DnaJ2 protein) (Heat shock protein 40 2); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds o [...] | 0.471 |
| clpP1 | dnaK1 | PFREUD_08240 | PFREUD_17840 | ATP-dependent Clp protease proteolytic subunit 1 (Endopeptidase Clp 1); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein dnaK 1 (Heat shock protein 70 1) (Heat shock 70 kDa protein 1) (HSP70 1); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.773 |
| clpP1 | dnaK2 | PFREUD_08240 | PFREUD_04630 | ATP-dependent Clp protease proteolytic subunit 1 (Endopeptidase Clp 1); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein dnaK 2 (Heat shock protein 70 2) (Heat shock 70 kDa protein 2) (HSP70 2); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.773 |
| clpP1 | grpE1 | PFREUD_08240 | PFREUD_17830 | ATP-dependent Clp protease proteolytic subunit 1 (Endopeptidase Clp 1); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Protein GrpE 1 (HSP-70 cofactor 1) (Co-chaperone protein GrpE1); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing th [...] | 0.751 |
| clpP1 | grpE2 | PFREUD_08240 | PFREUD_04640 | ATP-dependent Clp protease proteolytic subunit 1 (Endopeptidase Clp 1); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Protein GrpE 2 (HSP-70 cofactor 2) (Co-chaperone protein GrpE2); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing th [...] | 0.751 |
| clpP2 | clpC | PFREUD_08250 | PFREUD_20250 | ATP-dependent Clp protease proteolytic subunit 2 (Endopeptidase Clp 2); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone clpC (Clp-family ATP-binding protease) (ATP-dependent Clp protease ATP-binding subunit); Belongs to the clpA/clpB family. ClpC subfamily. The protein has been identified by proteomics as a 99 kDa protein induced by heat.Several 90 to 100 kda clp chaperones are expressed as disctinct heat shock proteins. | 0.874 |
| clpP2 | clpP1 | PFREUD_08250 | PFREUD_08240 | ATP-dependent Clp protease proteolytic subunit 2 (Endopeptidase Clp 2); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease proteolytic subunit 1 (Endopeptidase Clp 1); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.998 |
STRING v12.5 is now available!
