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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoEndonuclease IV (deoxyribonuclease IV (phage-T4-induced)); These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites. (267 aa)    
Predicted Functional Partners:
PPA2234
Putative long-chain-fatty-acid--CoA ligase/synthetase; ATP + Long-chain carboxylate + CoA <=> AMP + Pyrophosphate + Acyl-CoA and ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Pyrophosphate.
       0.799
cbiF
CbiF Precorrin-4 C11-methyltransferase; # S-Adenosyl-L-methionine + Precorrin 4 <=> S-Adenosyl-L-homocysteine + Precorrin 5.
      
 0.708
pyrF
Orotidine 5-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Orotidine 5 prime-phosphate <=> UMP + CO2.
     
 0.708
xthA
Exodeoxyribonuclease III/exonuclease III; Exonucleolytic cleavage in the 3 prime- to 5 prime -direction to yield nucleoside 5 prime-phosphates.
    
 
 0.672
nth
Putative endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.623
polA
Putative DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.537
alkA
AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase.
  
 
 
 0.480
CBL56498.1
5.2 Protein of unknown function similar to proteins from other organisms.
 
     0.475
sodA
Iron/Manganese superoxide dismutase (Superoxide dismutase [Mn/Fe]) (SODM); Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.453
uvrD
DNA helicase.
  
 
 0.451
Your Current Organism:
Propionibacterium freudenreichii
NCBI taxonomy Id: 754252
Other names: P. freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii ATCC 9614, Propionibacterium freudenreichii subsp. shermanii CIP 103027, Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii str. CIRM-BIA1, Propionibacterium freudenreichii subsp. shermanii strain CIRM-BIA1
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