STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
trpEAnthranilate synthase, aminase component; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...] (497 aa)    
Predicted Functional Partners:
trpC
PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family.
 
 0.999
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 0.999
Q7A_1674
Anthranilate synthase; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase.
 0.999
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.973
Q7A_1906
Anthranilate phosphoribosyltransferase; PFAM: Glycosyl transferase family, a/b domain; Glycosyl transferase family, helical bundle domain.
 
 0.963
PheA
PFAM: Prephenate dehydratase; Chorismate mutase type II; ACT domain; TIGRFAM: chorismate mutase domain of proteobacterial P-protein, clade 2.
 
 
 0.963
trpB
Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
  
 0.928
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.919
trpF
PFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family.
 
  
 0.916
PabB
PFAM: Anthranilate synthase component I, N terminal region; chorismate binding enzyme; TIGRFAM: aminodeoxychorismate synthase, component I, bacterial clade; aminodeoxychorismate synthase, component I, clade 2.
  
  
 
0.838
Your Current Organism:
Methylophaga nitratireducenticrescens
NCBI taxonomy Id: 754476
Other names: ATCC BAA-2433, DSM 25689, M. nitratireducenticrescens, Methylophaga nitratireducenticrescens Villeneuve et al. 2013, Methylophaga sp. GP59, Methylophaga sp. JAM1, strain JAM1
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