| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| KXB67409.1 | KXB68085.1 | HMPREF1863_00599 | HMPREF1863_00403 | KEGG: efa:EF1140 5.7e-39 gloA; lactoylglutathione lyase; K01759 lactoylglutathione lyase; Psort location: Cytoplasmic, score: 9.97. | KEGG: fma:FMG_1504 3.2e-61 L-serine dehydratase subunit beta; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.792 |
| KXB67409.1 | KXB68086.1 | HMPREF1863_00599 | HMPREF1863_00404 | KEGG: efa:EF1140 5.7e-39 gloA; lactoylglutathione lyase; K01759 lactoylglutathione lyase; Psort location: Cytoplasmic, score: 9.97. | KEGG: faa:HMPREF0389_01609 1.1e-72 L-serine dehydratase, iron-sulfur-dependent subunit alpha; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.26. | 0.793 |
| KXB68020.1 | KXB68085.1 | HMPREF1863_00337 | HMPREF1863_00403 | KEGG: ate:Athe_2254 1.0e-48 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | KEGG: fma:FMG_1504 3.2e-61 L-serine dehydratase subunit beta; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.779 |
| KXB68020.1 | KXB68086.1 | HMPREF1863_00337 | HMPREF1863_00404 | KEGG: ate:Athe_2254 1.0e-48 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | KEGG: faa:HMPREF0389_01609 1.1e-72 L-serine dehydratase, iron-sulfur-dependent subunit alpha; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.26. | 0.779 |
| KXB68020.1 | KXB68201.1 | HMPREF1863_00337 | HMPREF1863_00222 | KEGG: ate:Athe_2254 1.0e-48 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | KEGG: cle:Clole_1610 9.7e-60 homoserine dehydrogenase; K00003 homoserine dehydrogenase; Psort location: Cytoplasmic, score: 9.97. | 0.602 |
| KXB68020.1 | KXB68276.1 | HMPREF1863_00337 | HMPREF1863_00298 | KEGG: ate:Athe_2254 1.0e-48 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | HAD hydrolase, family IB; KEGG: cbj:H04402_02837 8.4e-22 phosphoserine phosphatase. | 0.632 |
| KXB68020.1 | glyA | HMPREF1863_00337 | HMPREF1863_01684 | KEGG: ate:Athe_2254 1.0e-48 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.791 |
| KXB68020.1 | serC | HMPREF1863_00337 | HMPREF1863_01156 | KEGG: ate:Athe_2254 1.0e-48 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | 0.512 |
| KXB68020.1 | thrB | HMPREF1863_00337 | HMPREF1863_00738 | KEGG: ate:Athe_2254 1.0e-48 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.862 |
| KXB68084.1 | KXB68085.1 | HMPREF1863_00402 | HMPREF1863_00403 | Dihydroorotase family protein; KEGG: csh:Closa_4136 2.8e-53 dihydroorotase, multifunctional complex type; K01465 dihydroorotase; Psort location: Cytoplasmic, score: 9.97. | KEGG: fma:FMG_1504 3.2e-61 L-serine dehydratase subunit beta; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.549 |
| KXB68084.1 | KXB68086.1 | HMPREF1863_00402 | HMPREF1863_00404 | Dihydroorotase family protein; KEGG: csh:Closa_4136 2.8e-53 dihydroorotase, multifunctional complex type; K01465 dihydroorotase; Psort location: Cytoplasmic, score: 9.97. | KEGG: faa:HMPREF0389_01609 1.1e-72 L-serine dehydratase, iron-sulfur-dependent subunit alpha; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.26. | 0.549 |
| KXB68085.1 | KXB67409.1 | HMPREF1863_00403 | HMPREF1863_00599 | KEGG: fma:FMG_1504 3.2e-61 L-serine dehydratase subunit beta; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the iron-sulfur dependent L-serine dehydratase family. | KEGG: efa:EF1140 5.7e-39 gloA; lactoylglutathione lyase; K01759 lactoylglutathione lyase; Psort location: Cytoplasmic, score: 9.97. | 0.792 |
| KXB68085.1 | KXB68020.1 | HMPREF1863_00403 | HMPREF1863_00337 | KEGG: fma:FMG_1504 3.2e-61 L-serine dehydratase subunit beta; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the iron-sulfur dependent L-serine dehydratase family. | KEGG: ate:Athe_2254 1.0e-48 serine O-acetyltransferase K00640; Psort location: Cytoplasmic, score: 9.97. | 0.779 |
| KXB68085.1 | KXB68084.1 | HMPREF1863_00403 | HMPREF1863_00402 | KEGG: fma:FMG_1504 3.2e-61 L-serine dehydratase subunit beta; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Dihydroorotase family protein; KEGG: csh:Closa_4136 2.8e-53 dihydroorotase, multifunctional complex type; K01465 dihydroorotase; Psort location: Cytoplasmic, score: 9.97. | 0.549 |
| KXB68085.1 | KXB68086.1 | HMPREF1863_00403 | HMPREF1863_00404 | KEGG: fma:FMG_1504 3.2e-61 L-serine dehydratase subunit beta; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the iron-sulfur dependent L-serine dehydratase family. | KEGG: faa:HMPREF0389_01609 1.1e-72 L-serine dehydratase, iron-sulfur-dependent subunit alpha; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.26. | 0.999 |
| KXB68085.1 | KXB68087.1 | HMPREF1863_00403 | HMPREF1863_00405 | KEGG: fma:FMG_1504 3.2e-61 L-serine dehydratase subunit beta; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the iron-sulfur dependent L-serine dehydratase family. | UBA/TS-N domain protein; Psort location: Cytoplasmic, score: 8.96. | 0.506 |
| KXB68085.1 | KXB68201.1 | HMPREF1863_00403 | HMPREF1863_00222 | KEGG: fma:FMG_1504 3.2e-61 L-serine dehydratase subunit beta; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the iron-sulfur dependent L-serine dehydratase family. | KEGG: cle:Clole_1610 9.7e-60 homoserine dehydrogenase; K00003 homoserine dehydrogenase; Psort location: Cytoplasmic, score: 9.97. | 0.785 |
| KXB68085.1 | KXB68276.1 | HMPREF1863_00403 | HMPREF1863_00298 | KEGG: fma:FMG_1504 3.2e-61 L-serine dehydratase subunit beta; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the iron-sulfur dependent L-serine dehydratase family. | HAD hydrolase, family IB; KEGG: cbj:H04402_02837 8.4e-22 phosphoserine phosphatase. | 0.500 |
| KXB68085.1 | glyA | HMPREF1863_00403 | HMPREF1863_01684 | KEGG: fma:FMG_1504 3.2e-61 L-serine dehydratase subunit beta; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.903 |
| KXB68085.1 | serC | HMPREF1863_00403 | HMPREF1863_01156 | KEGG: fma:FMG_1504 3.2e-61 L-serine dehydratase subunit beta; K01752 L-serine dehydratase; Psort location: Cytoplasmic, score: 9.97; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. | 0.539 |