STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (689 aa)    
Predicted Functional Partners:
leuS
leucine--tRNA ligase; KEGG: aoe:Clos_2587 0. leuS; leucyl-tRNA synthetase; K01869 leucyl-tRNA synthetase; Psort location: Cytoplasmic, score: 9.97; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 
 0.981
KXB65387.1
KEGG: txy:Thexy_1943 0. pyruvate ferredoxin/flavodoxin oxidoreductase K03737; Psort location: Cytoplasmic, score: 8.96.
  
   0.968
KXB65227.1
KEGG: fma:FMG_0385 0. pyruvate/ferredoxin oxidoreductase; K03737 putative pyruvate-flavodoxin oxidoreductase; Psort location: Cytoplasmic, score: 8.96.
  
   0.968
KXB65328.1
KEGG: shn:Shewana3_3590 2.3e-12 single-strand binding protein K03111; Psort location: Cytoplasmic, score: 9.26.
  
 
 0.957
rpoA
DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.909
polA
DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
 0.891
KXB64994.1
Prepilin-type cleavage/methylation protein; KEGG: cco:CCC13826_1487 0.0022 carbamoyl-phosphate synthase large subunit.
     
 0.876
KXB64990.1
DNA protecting protein DprA; KEGG: pfe:PSF113_0071 7.1e-41 smf; protein Smf K04096; Psort location: Cytoplasmic, score: 8.96.
   
 0.857
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.835
KXB65067.1
RecF/RecN/SMC protein; KEGG: bce:BC1852 1.6e-34 exonuclease SbcC K03546; Psort location: Cytoplasmic, score: 8.96.
  
 0.827
Your Current Organism:
Peptoniphilus coxii
NCBI taxonomy Id: 755172
Other names: ATCC BAA-2106, CCUG 59622, JCM 16892, P. coxii, Peptoniphilus coxii Citron et al. 2013, Peptoniphilus sp. RMA 16757, strain RMA 16757
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