STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polADNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (879 aa)    
Predicted Functional Partners:
KXB68290.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
 
 0.999
KXB66659.1
KEGG: efc:EFAU004_02529 1.3e-09 Ser/Thr protein phosphatase family protein; Psort location: Cytoplasmic, score: 8.96.
  
 0.996
KXB65068.1
Ser/Thr phosphatase family protein; KEGG: bce:BC1857 7.3e-39 exonuclease SbcD K03547; Psort location: Cytoplasmic, score: 8.96.
  
 0.996
mutS
DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
   
 0.995
mutL
DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 0.994
KXB64923.1
Type III restriction enzyme, res subunit; KEGG: crd:CRES_1547 3.0e-143 DNA repair and recombination protein; Psort location: Cytoplasmic, score: 8.96.
  
 0.994
KXB65067.1
RecF/RecN/SMC protein; KEGG: bce:BC1852 1.6e-34 exonuclease SbcC K03546; Psort location: Cytoplasmic, score: 8.96.
  
 0.992
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
 
 0.991
KXB68415.1
Exodeoxyribonuclease III; KEGG: ere:EUBREC_0501 9.5e-101 exodeoxyribonuclease; K01142 exodeoxyribonuclease III; Psort location: Cytoplasmic, score: 9.97.
  
 0.981
asnS
asparagine--tRNA ligase; KEGG: cth:Cthe_0070 1.3e-176 asnC; asparaginyl-tRNA synthetase K01893; Psort location: Cytoplasmic, score: 10.00.
  
 0.981
Your Current Organism:
Peptoniphilus coxii
NCBI taxonomy Id: 755172
Other names: ATCC BAA-2106, CCUG 59622, JCM 16892, P. coxii, Peptoniphilus coxii Citron et al. 2013, Peptoniphilus sp. RMA 16757, strain RMA 16757
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