STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AFZ52923.1PFAM: Response regulator receiver domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR001789; KEGG: cyc:PCC7424_5086 response regulator receiver modulated diguanylate cyclase; PFAM: Diguanylate cyclase, predicted; Signal transduction response regulator, receiver domain; SMART: Diguanylate cyclase, predicted; Signal transduction response regulator, receiver domain; SPTR: Response regulator receiver modulated diguanylate cyclase; TIGRFAM: Diguanylate cyclase, p [...] (450 aa)    
Predicted Functional Partners:
AFZ53247.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; His Kinase A (phosphoacceptor) domain; COGs: COG2205 Osmosensitive K+ channel histidine kinase; InterPro IPR003018:IPR003661:IPR003594; KEGG: aci:ACIAD3176 putative sensory transduction histidine kinase; PFAM: ATPase-like, ATP-binding domain; GAF; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; GAF; SPTR: Putative uncharacterized protein.
 
     0.946
AFZ54406.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; GAF domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR013656:IPR003018:IPR003661:IPR003594:IPR 001789:IPR000014; KEGG: tel:tll1282 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-4; GAF; Signal transduction response regulator, receiver domain; SMART: ATPase-like, AT [...]
 
 0.938
AFZ54094.1
Diguanylate phosphodiesterase; PFAM: EAL domain; COGs: COG2200 FOG: EAL domain; InterPro IPR001633; KEGG: nwa:Nwat_1515 GAF/PAS/PAC sensor(S)-containing diguanylate cyclase/phosphodiesterase; PFAM: Diguanylate phosphodiesterase, predicted; SMART: Diguanylate phosphodiesterase, predicted; SPTR: Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S).
 
 
   0.920
AFZ53278.1
Diguanylate phosphodiesterase; PFAM: EAL domain; Cyclic nucleotide-binding domain; COGs: COG2200 FOG: EAL domain; InterPro IPR000595:IPR001633; KEGG: syn:slr0842 hypothetical protein; PFAM: Diguanylate phosphodiesterase, predicted; Cyclic nucleotide-binding; SMART: Diguanylate phosphodiesterase, predicted; Cyclic nucleotide-binding; SPTR: Slr0842 protein.
 
 
 
 0.915
AFZ55219.1
PFAM: Response regulator receiver domain; GGDEF domain; PAS fold; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789:IPR000160; KEGG: cyc:PCC7424_5086 response regulator receiver modulated diguanylate cyclase; PFAM: Diguanylate cyclase, predicted; Signal transduction response regulator, receiver domain; SMART: Diguanylate cyclase, predicted; Signal transduction response regulator, receiver domain; SPTR: Regulatory components of sensory transduction system; TIGRFAM: Diguanylate cycla [...]
  
  
 
0.903
AFZ53969.1
PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR001610:IPR003661:IPR003594:IPR 001789:IPR013655:IPR003018; KEGG: gfo:GFO_0848 two-component system sensor histidine kinase/response regulator hybrid; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-3; GAF; Signal transduction response regulator, receiver do [...]
 
0.901
AFZ52836.1
PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR003018:IPR001610:IPR003661:IPR 003594:IPR001789:IPR013655; KEGG: ava:Ava_4701 multi-sensor hybrid histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; GAF; PAS fold-3; Signal transduction response regulator, receiver domain; SMART: ATPase-like, ATP-bind [...]
 
0.898
AFZ54040.1
Response regulator receiver modulated metal dependent phosphohydrolase; PFAM: HD domain; Response regulator receiver domain; COGs: COG3437 Response regulator containing a CheY-like receiver domain and an HD-GYP domain; InterPro IPR001789:IPR006674; KEGG: cyh:Cyan8802_0839 response regulator receiver modulated metal dependent phosphohydrolase; PFAM: Signal transduction response regulator, receiver domain; Metal-dependent phosphohydrolase, HD subdomain; SMART: Signal transduction response regulator, receiver domain; SPTR: Response regulator receiver modulated metal dependent phosphohydrolase.
 
   
0.879
AFZ54028.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594; KEGG: cyh:Cyan8802_1611 GAF sensor signal transduction histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SMART: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; SPTR: GAF sensor signal transduction histidine kinase.
 
   0.878
AFZ52260.1
PAS/PAC sensor hybrid histidine kinase; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR001610:IPR003661:IPR003594:IPR 001789:IPR013767:IPR013655:IPR013656; KEGG: amr:AM1_5107 serine/threonine protein kinase and signal transduction histidine kinase (STHK) with GAF and PAS/PAC sensor; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosp [...]
 
 0.842
Your Current Organism:
Cyanobacterium aponinum
NCBI taxonomy Id: 755178
Other names: C. aponinum PCC 10605, Cyanobacterium aponinum PCC 10605, Cyanobacterium sp. PCC 10605
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.