STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dacAHypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (308 aa)    
Predicted Functional Partners:
cofH
FO synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine.
      
 0.794
mutS2
MutS2 protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
 
     0.628
AFZ54360.1
PFAM: Nicotinate phosphoribosyltransferase (NAPRTase) family; COGs: COG1488 Nicotinic acid phosphoribosyltransferase; InterPro IPR015977; KEGG: acb:A1S_1780 putative nicotinate phosphoribosyltransferase; PFAM: Nicotinate phosphoribosyltransferase-like; PRIAM: Nicotinamide phosphoribosyltransferase; SPTR: Putative nicotinamide phosphoribosyl transferase; Belongs to the NAPRTase family.
  
    0.546
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
     
 0.514
AFZ55239.1
PFAM: HD domain; 7TM-HD extracellular; 7TM receptor with intracellular HD hydrolase; TIGRFAM: uncharacterized domain HDIG; COGs: COG1480 membrane-associated HD superfamily hydrolase; InterPro IPR011621:IPR006674:IPR006675:IPR003607; KEGG: cyh:Cyan8802_0071 7TM receptor with intracellular metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, 7TM intracellular domain; Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: 7TM receptor with intracellular metal dependent phosphohydrolase; TIGRFAM: HDIG.
 
  
 0.494
queE
Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
      
 0.459
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
       0.457
azoR
FMN-dependent NADH-azoreductase; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity; Belongs to the azoreductase type 1 family.
      
 0.446
AFZ55516.1
Polynucleotide adenylyltransferase region; PFAM: DHH family; CBS domain; Poly A polymerase head domain; COGs: COG0617 tRNA nucleotidyltransferase/poly(A) polymerase; InterPro IPR000644:IPR001667:IPR002646; KEGG: cyc:PCC7424_2388 polynucleotide adenylyltransferase region; PFAM: Poly A polymerase, head domain; Cystathionine beta-synthase, core; Phosphoesterase, RecJ-like; SMART: Cystathionine beta-synthase, core; SPTR: Polynucleotide adenylyltransferase region; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
     
 0.417
AFZ54409.1
PFAM: Domain of unknown function (DUF814); Fibronectin-binding protein A N-terminus (FbpA); COGs: COG1293 RNA-binding protein homologous to eukaryotic snRNP; InterPro IPR008616:IPR008532; KEGG: cyt:cce_0415 hypothetical protein; PFAM: Fibronectin-binding A, N-terminal; Protein of unknown function DUF814; SPTR: Putative uncharacterized protein.
 
     0.401
Your Current Organism:
Cyanobacterium aponinum
NCBI taxonomy Id: 755178
Other names: C. aponinum PCC 10605, Cyanobacterium aponinum PCC 10605, Cyanobacterium sp. PCC 10605
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