STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
menD2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. (566 aa)    
Predicted Functional Partners:
AEA42287.1
Chorismate binding domain-containing protein; COGs: COG1169 Isochorismate synthase; InterPro IPR015890; KEGG: zpr:ZPR_1714 isochorismate synthase; PFAM: Chorismate binding, C-terminal; SPTR: Isochorismate synthase; PFAM: chorismate binding enzyme.
 
 
 0.991
menB
1,4-Dihydroxy-2-naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA).
 
  
 0.873
AEA45351.1
O-succinylbenzoate--CoA ligase; COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; KEGG: fps:FP1601 O-succinylbenzoate--CoA ligase; SPTR: Putative uncharacterized protein; PFAM: AMP-binding enzyme.
 
  
 0.860
AEA42209.1
Mandelate racemase/muconate lactonizing protein; COGs: COG4948 L-alanine-DL-glutamate epimerase; InterPro IPR013342; KEGG: gfo:GFO_2310 O-succinylbenzoate synthase; PFAM: Mandelate racemase/muconate lactonizing enzyme, C-terminal; SPTR: Chloromuconate cycloisomerase; PFAM: Mandelate racemase / muconate lactonizing enzyme, C-terminal domain; TIGRFAM: o-succinylbenzoic acid (OSB) synthetase.
 
   
 0.857
menA
1,4-dihydroxy-2-naphtoate prenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
 
   
 0.856
AEA42288.1
Phenylacetic acid degradation-related protein; COGs: COG2050 Uncharacterized protein possibly involved in aromatic compounds catabolism; InterPro IPR006683:IPR003736; KEGG: rmr:Rmar_1468 thioesterase superfamily protein; PFAM: Thioesterase superfamily; SPTR: Thioesterase superfamily protein; TIGRFAM: Phenylacetic acid degradation-related protein; PFAM: Thioesterase superfamily; TIGRFAM: uncharacterized domain 1.
 
   
 0.765
AEA42286.1
KEGG: mja:MJ_0795 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.504
AEA42282.1
KEGG: rbi:RB2501_13664 hypothetical protein; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF493).
 
     0.451
Your Current Organism:
Fluviicola taffensis
NCBI taxonomy Id: 755732
Other names: CFB group bacterium RW262, F. taffensis DSM 16823, Fluviicola taffensis DSM 16823, Fluviicola taffensis RW262, Fluviicola taffensis str. DSM 16823, Fluviicola taffensis strain DSM 16823
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.