STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa)    
Predicted Functional Partners:
ADY60226.1
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR005932: IPR002872: IPR015590; KEGG: psl:Psta_0870 delta-1-pyrroline-5-carboxylate dehydrogenase; PFAM: Aldehyde dehydrogenase; Proline dehydrogenase; SPTR: 1-pyrroline-5 carboxylate dehydrogenase; TIGRFAM: Delta-1-pyrroline-5-carboxylate dehydrogenase 2; PFAM: Proline dehydrogenase; Aldehyde dehydrogenase family; TIGRFAM: delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Belongs to the aldehyde dehydrogenase family.
   
 0.946
ADY60839.1
4-hydroxyproline epimerase; COGs: COG3938 Proline racemase; InterPro IPR008794; KEGG: bgf:BC1003_5297 4-hydroxyproline epimerase; PFAM: Proline racemase; PRIAM: 4-hydroxyproline epimerase; SPTR: Proline racemase; PFAM: Proline racemase; Belongs to the proline racemase family.
    
 0.917
proB
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
 
 0.907
rnhA
RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
      0.841
proA
Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 
 0.802
ADY61598.1
Protein of unknown function UPF0001; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
  
 0.748
ADY57645.1
COGs: COG0509 Glycine cleavage system H protein (lipoate-binding); InterPro IPR002930; KEGG: psl:Psta_4504 glycine cleavage H-protein; PFAM: Glycine cleavage H-protein; SPTR: Glycine cleavage system H protein 1; PFAM: Glycine cleavage H-protein.
       0.590
ADY57647.1
COGs: COG1643 HrpA-like helicase; InterPro IPR001650: IPR007502: IPR011709: IPR014001: IPR 003593: IPR010222; KEGG: nhl:Nhal_1290 ATP-dependent helicase HrpA; PFAM: Helicase-associated domain; DNA/RNA helicase, C-terminal; Domain of unknown function DUF1605; SMART: DEAD-like helicase, N-terminal; ATPase, AAA+ type, core; DNA/RNA helicase, C-terminal; SPTR: ATP-dependent helicase HrpA; TIGRFAM: RNA helicase, ATP-dependent DEAH box, HrpA type; PFAM: Helicase conserved C-terminal domain; Helicase associated domain (HA2); Domain of unknown function (DUF3418); Domain of unknown function (DU [...]
 
     0.580
ADY58195.1
Glutamate synthase (NADH) large subunit; COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583: IPR006982: IPR002932: IPR002489; KEGG: plm:Plim_2694 glutamate synthase (NADH); PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (NADH); SPTR: Glutamate synthase (NADH); PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
     
 0.534
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.474
Your Current Organism:
Rubinisphaera brasiliensis
NCBI taxonomy Id: 756272
Other names: Planctomyces brasiliensis ATCC 49424, Planctomyces brasiliensis DSM 5305, Planctomyces brasiliensis str. DSM 5305, Planctomyces brasiliensis strain DSM 5305, R. brasiliensis DSM 5305, Rubinisphaera brasiliensis DSM 5305
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.