STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
ADY61171.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1184 aa)    
Predicted Functional Partners:
ADY57935.1
COGs: COG0372 Citrate synthase; InterPro IPR011278: IPR002020; KEGG: plm:Plim_0895 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase type I; PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.
  
 0.940
ADY58088.1
COGs: COG0469 Pyruvate kinase; InterPro IPR001697: IPR015793: IPR015794; KEGG: plm:Plim_3274 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family.
   
 0.937
ADY60452.1
2-oxoacid:acceptor oxidoreductase, alpha subunit; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR019752: IPR002880; KEGG: rba:RB6935 2-oxoglutarate ferredoxin oxidoreductase alpha subunit; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal; Pyruvate/ketoisovalerate oxidoreductase, catalytic domain; PRIAM: 2-oxoglutarate synthase; SPTR: 2-oxoglutarate ferredoxin oxidoreductase alpha subunit; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, alpha subunit; PFAM: domain; Pyruvate ferredoxin/flavodoxin oxid [...]
     
 0.935
ADY61266.1
COGs: COG0340 Biotin-(acetyl-CoA carboxylase) ligase; InterPro IPR004143: IPR003142: IPR004408; KEGG: psl:Psta_2727 biotin/acetyl-CoA-carboxylase ligase; PFAM: Biotin/lipoate A/B protein ligase; Biotin protein ligase, C-terminal; SPTR: Biotin [acetyl-CoA-carboxylase] ligase; TIGRFAM: Biotin--acetyl-CoA-carboxylase ligase; PFAM: Biotin protein ligase C terminal domain; Biotin/lipoate A/B protein ligase family; TIGRFAM: birA, biotin-[acetyl-CoA-carboxylase] ligase region.
 
 0.932
mdh
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.930
ADY61182.1
Pyruvate phosphate dikinase; COGs: COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; InterPro IPR002192: IPR008279: IPR000121: IPR010121; KEGG: plm:Plim_2420 pyruvate, phosphate dikinase; PFAM: Pyruvate phosphate dikinase, PEP/pyruvate-binding; PEP-utilising enzyme, mobile domain; PEP-utilising enzyme; PRIAM: Pyruvate, phosphate dikinase; SPTR: Pyruvate phosphate dikinase; TIGRFAM: Pyruvate, phosphate dikinase; PFAM: PEP-utilising enzyme, mobile domain; PEP-utilising enzyme, TIM barrel domain; Pyruvate phosphate dikinase, PEP/pyruvate binding domain; TIGRFAM: pyruvate, [...]
  
 
 0.923
pckA
Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
    
 0.920
ADY60451.1
2-oxoglutarate synthase; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: psl:Psta_0806 thiamine pyrophosphate protein domain protein TPP-binding protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; PRIAM: 2-oxoglutarate synthase; SPTR: 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
     
 0.917
ADY62103.1
2-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.910
ADY62220.1
COGs: COG1052 Lactate dehydrogenase and related dehydrogenase; InterPro IPR006139: IPR006140; KEGG: maq:Maqu_3853 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; PRIAM: D-lactate dehydrogenase; SPTR: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain.
   
 
 0.902
Your Current Organism:
Rubinisphaera brasiliensis
NCBI taxonomy Id: 756272
Other names: Planctomyces brasiliensis ATCC 49424, Planctomyces brasiliensis DSM 5305, Planctomyces brasiliensis str. DSM 5305, Planctomyces brasiliensis strain DSM 5305, R. brasiliensis DSM 5305, Rubinisphaera brasiliensis DSM 5305
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