STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLCOGs: COG0001 Glutamate-1-semialdehyde aminotransferase; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; InterPro IPR005814: IPR004639; KEGG: plm:Plim_2747 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; PRIAM: Glutamate-1-semialdehyde 2,1-aminomutase; SPTR: Probable glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. (428 aa)    
Predicted Functional Partners:
ADY61588.1
Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: hoh:Hoch_3924 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Delta-aminolevulinic acid dehydratase; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.993
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.987
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.957
ADY60748.1
6-methylsalicylic acid synthase., 6-deoxyerythronolide-B synthase; COGs: COG3321 Polyketide synthase modules and related protein; InterPro IPR014030: IPR014031: IPR014043: IPR013968: IPR 006163; KEGG: mau:Micau_2464 beta-ketoacyl synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Beta-ketoacyl synthase, C-terminal; Acyl transferase; Polyketide synthase, KR; Phosphopantetheine-binding; PRIAM: 6-methylsalicylic acid synthase., 6-deoxyerythronolide-B synthase; SPTR: Polyketide synthase type I; PFAM: Phosphopantetheine attachment site; Acyl transferase domain; KR domain; Beta-ketoacyl syn [...]
    
 0.910
ADY59687.1
COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366: IPR000878: IPR003754; KEGG: plm:Plim_1555 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; PRIAM: Uroporphyrinogen-III C-methyltransferase., Uroporphyrinogen-III synthase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase.
 
  
 0.868
ADY61052.1
COGs: COG0304 3-oxoacyl-(acyl-carrier-protein) synthase; InterPro IPR014030: IPR014031; KEGG: caa:Caka_1850 beta-ketoacyl synthase; PFAM: Beta-ketoacyl synthase, N-terminal; Beta-ketoacyl synthase, C-terminal; PRIAM: Beta-ketoacyl-acyl-carrier-protein synthase I; SPTR: 3-oxoacyl-[acyl-carrier-protein] synthase II; PFAM: Beta-ketoacyl synthase, N-terminal domain; Beta-ketoacyl synthase, C-terminal domain; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
 
 
  
 0.758
ADY60101.1
3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
 
 
  
 0.740
ADY60109.1
COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR004410: IPR014043; KEGG: plm:Plim_2566 malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; PRIAM: [Acyl-carrier-protein] S-malonyltransferase; SPTR: Malonyl CoA-acyl carrier protein transacylase; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase.
    
 0.672
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.598
ADY60530.1
3-oxoacyl-(acyl-carrier-protein) synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
 
 
  
 0.568
Your Current Organism:
Rubinisphaera brasiliensis
NCBI taxonomy Id: 756272
Other names: Planctomyces brasiliensis ATCC 49424, Planctomyces brasiliensis DSM 5305, Planctomyces brasiliensis str. DSM 5305, Planctomyces brasiliensis strain DSM 5305, R. brasiliensis DSM 5305, Rubinisphaera brasiliensis DSM 5305
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