Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AFM01108.1Precorrin-2 dehydrogenase; PFAM: Sirohaem synthase dimerisation region; TIGRFAM: siroheme synthase, N-terminal domain. (212 aa)    
Predicted Functional Partners:
AFM01105.1
PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase; uroporphyrinogen-III synthase.
 
 0.999
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.977
AFL99659.1
Cobalt-precorrin 4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family.
   
 0.969
AFL99658.1
Precorrin-2 C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase; cobalt-factor II C20-methyltransferase.
    
 0.947
hemL
PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase.
   
 0.937
AFM01103.1
PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
   
 0.912
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
   
 0.912
AFM01104.1
PFAM: Radical SAM superfamily; TIGRFAM: putative heme d1 biosynthesis radical SAM protein NirJ1; radical SAM additional 4Fe4S-binding domain.
 
     0.875
AFL99663.1
Hypothetical protein; PFAM: CbiX.
  
  
 0.866
AFM01101.1
Transcriptional regulator.
 
     0.861
Your Current Organism:
Desulfitobacterium dehalogenans
NCBI taxonomy Id: 756499
Other names: D. dehalogenans ATCC 51507, Desulfitobacterium dehalogenans ATCC 51507, Desulfitobacterium dehalogenans DSM 9161, Desulfitobacterium dehalogenans JW/IU-DC1, Desulfitobacterium dehalogenans str. ATCC 51507, Desulfitobacterium dehalogenans strain ATCC 51507
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