| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEN04507.1 | AEN04560.1 | Halar_0736 | Halar_0789 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | 0.816 |
| AEN04507.1 | AEN04606.1 | Halar_0736 | Halar_0838 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | KEGG: hla:Hlac_0782 small GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | 0.606 |
| AEN04507.1 | AEN06309.1 | Halar_0736 | Halar_2662 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | KEGG: nmg:Nmag_3589 beta-lactamase domain protein. | 0.640 |
| AEN04507.1 | AEN06687.1 | Halar_0736 | Halar_3062 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | KEGG: hla:Hlac_0818 translation initiation factor IF-2 subunit beta; PFAM: Translation initiation factor IF2/IF5; Deoxyribonuclease/rho motif-related TRAM; SMART: Translation initiation factor IF2/IF5. | 0.639 |
| AEN04507.1 | dphB | Halar_0736 | Halar_0827 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.953 |
| AEN04507.1 | fusA | Halar_0736 | Halar_0928 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.984 |
| AEN04507.1 | pcn | Halar_0736 | Halar_3180 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.709 |
| AEN04507.1 | prf1 | Halar_0736 | Halar_2885 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.611 |
| AEN04507.1 | rpl10e | Halar_0736 | Halar_1027 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | TIGRFAM: Ribosomal protein L10e; HAMAP: 50S ribosomal protein L10e; KEGG: hla:Hlac_0057 50S ribosomal protein L10e; PFAM: Ribosomal protein L10e/L16; Belongs to the universal ribosomal protein uL16 family. | 0.806 |
| AEN04507.1 | rps4e | Halar_0736 | Halar_2469 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | KEGG: hvo:HVO_2552 30S ribosomal protein S4.eR; HAMAP: 30S ribosomal protein S4e; PFAM: Ribosomal protein S4e, central; Ribosomal protein S4e, N-terminal; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.627 |
| AEN04560.1 | AEN04507.1 | Halar_0789 | Halar_0736 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.816 |
| AEN04560.1 | AEN06687.1 | Halar_0789 | Halar_3062 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | KEGG: hla:Hlac_0818 translation initiation factor IF-2 subunit beta; PFAM: Translation initiation factor IF2/IF5; Deoxyribonuclease/rho motif-related TRAM; SMART: Translation initiation factor IF2/IF5. | 0.408 |
| AEN04560.1 | dphB | Halar_0789 | Halar_0827 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.900 |
| AEN04560.1 | fusA | Halar_0789 | Halar_0928 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.929 |
| AEN04606.1 | AEN04507.1 | Halar_0838 | Halar_0736 | KEGG: hla:Hlac_0782 small GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.606 |
| AEN04606.1 | AEN06687.1 | Halar_0838 | Halar_3062 | KEGG: hla:Hlac_0782 small GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | KEGG: hla:Hlac_0818 translation initiation factor IF-2 subunit beta; PFAM: Translation initiation factor IF2/IF5; Deoxyribonuclease/rho motif-related TRAM; SMART: Translation initiation factor IF2/IF5. | 0.663 |
| AEN04606.1 | dphB | Halar_0838 | Halar_0827 | KEGG: hla:Hlac_0782 small GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.704 |
| AEN04606.1 | fusA | Halar_0838 | Halar_0928 | KEGG: hla:Hlac_0782 small GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.580 |
| AEN04606.1 | prf1 | Halar_0838 | Halar_2885 | KEGG: hla:Hlac_0782 small GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | Peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.711 |
| AEN04606.1 | rpl10e | Halar_0838 | Halar_1027 | KEGG: hla:Hlac_0782 small GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | TIGRFAM: Ribosomal protein L10e; HAMAP: 50S ribosomal protein L10e; KEGG: hla:Hlac_0057 50S ribosomal protein L10e; PFAM: Ribosomal protein L10e/L16; Belongs to the universal ribosomal protein uL16 family. | 0.663 |
