Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN04510.1PFAM: Peptidase S1/S6, chymotrypsin/Hap; KEGG: hma:rrnAC0296 serine protease HtrA. (342 aa)    
Predicted Functional Partners:
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
   
 0.946
pan
Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...]
   
 0.892
AEN06328.1
SMART: ATPase, AAA+ type, core; TIGRFAM: 26S proteasome subunit P45; KEGG: hbo:Hbor_05530 proteasome-activating nucleotidase; PFAM: ATPase, AAA-type, core; Belongs to the AAA ATPase family.
   
 0.892
AEN06577.1
TIGRFAM: Peptidase S26B, eukaryotic signal peptidase; KEGG: hvo:HVO_0002 signal peptidase I.
  
 
 0.834
AEN04927.1
Mov34/MPN/PAD-1 family protein; PFAM: Mov34/MPN/PAD-1; KEGG: hbo:Hbor_21950 proteasome rpn11 subunit jamm motif protein.
  
 0.763
AEN05625.1
KEGG: hla:Hlac_1268 Mov34/MPN/PAD-1 family protein; PFAM: Mov34/MPN/PAD-1; SMART: Mov34/MPN/PAD-1.
  
 0.763
rpl11
Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family.
 
 
   0.718
dnaK
Chaperone protein dnaK; Acts as a chaperone.
 
 
 0.710
rps9
KEGG: hwa:HQ2938A 30S ribosomal protein S9P; TIGRFAM: Ribosomal protein S9, archaeal; PFAM: Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family.
   
 
 0.671
rps13
Ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family.
   
   0.657
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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