| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEN04507.1 | AEN04560.1 | Halar_0736 | Halar_0789 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | 0.816 |
| AEN04507.1 | dacZ | Halar_0736 | Halar_0747 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.521 |
| AEN04507.1 | hisC | Halar_0736 | Halar_3537 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: Aminotransferase, class I/II; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: hvo:HVO_1295 histidinol-phosphate aminotransferase. | 0.403 |
| AEN04507.1 | nadK | Halar_0736 | Halar_1825 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.477 |
| AEN04507.1 | rpl37ae | Halar_0736 | Halar_0995 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Ribosomal L37ae protein; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family. | 0.512 |
| AEN04517.1 | AEN04519.1 | Halar_0746 | Halar_0748 | PFAM: Mechanosensitive ion channel MscS; KEGG: hla:Hlac_1441 mechanosensitive ion channel. | Protein of unknown function UPF0118; PFAM: Uncharacterised protein family UPF0118; KEGG: hma:rrnAC3369 hypothetical protein. | 0.630 |
| AEN04517.1 | dacZ | Halar_0746 | Halar_0747 | PFAM: Mechanosensitive ion channel MscS; KEGG: hla:Hlac_1441 mechanosensitive ion channel. | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.935 |
| AEN04519.1 | AEN04517.1 | Halar_0748 | Halar_0746 | Protein of unknown function UPF0118; PFAM: Uncharacterised protein family UPF0118; KEGG: hma:rrnAC3369 hypothetical protein. | PFAM: Mechanosensitive ion channel MscS; KEGG: hla:Hlac_1441 mechanosensitive ion channel. | 0.630 |
| AEN04519.1 | dacZ | Halar_0748 | Halar_0747 | Protein of unknown function UPF0118; PFAM: Uncharacterised protein family UPF0118; KEGG: hma:rrnAC3369 hypothetical protein. | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.608 |
| AEN04560.1 | AEN04507.1 | Halar_0789 | Halar_0736 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.816 |
| AEN04560.1 | dacZ | Halar_0789 | Halar_0747 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.496 |
| AEN04560.1 | hisC | Halar_0789 | Halar_3537 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | PFAM: Aminotransferase, class I/II; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: hvo:HVO_1295 histidinol-phosphate aminotransferase. | 0.465 |
| AEN04560.1 | nadK | Halar_0789 | Halar_1825 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.553 |
| AEN04560.1 | rpl37ae | Halar_0789 | Halar_0995 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Ribosomal L37ae protein; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family. | 0.425 |
| AEN05074.1 | dacZ | Halar_1328 | Halar_0747 | PFAM: Phosphoesterase, RecJ-like; Phosphoesterase, DHHA1; KEGG: hla:Hlac_0324 phosphoesterase RecJ domain protein. | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.526 |
| AEN06270.1 | dacZ | Halar_2621 | Halar_0747 | TrkA-N domain protein; PFAM: Regulator of K+ conductance, N-terminal; Phosphoesterase, RecJ-like; KEGG: hbo:Hbor_15210 k+ transporter, NAD-binding component,exopolyphosphatase-like enzyme. | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.515 |
| AEN06685.1 | dacZ | Halar_3060 | Halar_0747 | CopG-like domain-containing protein DNA-binding domain; PFAM: CopG-like DNA-binding; KEGG: nmg:Nmag_0981 putative transcriptional regulator, CopG/Arc/MetJ family. | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.528 |
| dacZ | AEN04507.1 | Halar_0747 | Halar_0736 | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.521 |
| dacZ | AEN04517.1 | Halar_0747 | Halar_0746 | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | PFAM: Mechanosensitive ion channel MscS; KEGG: hla:Hlac_1441 mechanosensitive ion channel. | 0.935 |
| dacZ | AEN04519.1 | Halar_0747 | Halar_0748 | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | Protein of unknown function UPF0118; PFAM: Uncharacterised protein family UPF0118; KEGG: hma:rrnAC3369 hypothetical protein. | 0.608 |
