| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEN04507.1 | AEN04560.1 | Halar_0736 | Halar_0789 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | 0.816 |
| AEN04507.1 | dacZ | Halar_0736 | Halar_0747 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.521 |
| AEN04507.1 | dphB | Halar_0736 | Halar_0827 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.953 |
| AEN04507.1 | fusA | Halar_0736 | Halar_0928 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.984 |
| AEN04507.1 | hisC | Halar_0736 | Halar_3537 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: Aminotransferase, class I/II; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: hvo:HVO_1295 histidinol-phosphate aminotransferase. | 0.403 |
| AEN04507.1 | mptA | Halar_0736 | Halar_1782 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Protein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.497 |
| AEN04507.1 | nadK | Halar_0736 | Halar_1825 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.477 |
| AEN04507.1 | rpl19e | Halar_0736 | Halar_2463 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. | 0.534 |
| AEN04560.1 | AEN04507.1 | Halar_0789 | Halar_0736 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.816 |
| AEN04560.1 | AEN04561.1 | Halar_0789 | Halar_0790 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | PFAM: Phosphoadenosine phosphosulphate reductase; KEGG: hvo:HVO_1079 sulfate adenylyltransferase small subunit. | 0.552 |
| AEN04560.1 | AEN07106.1 | Halar_0789 | Halar_3512 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | PFAM: Asparagine synthase; KEGG: hbo:Hbor_22320 asparagine synthase (glutamine-hydrolyzing). | 0.725 |
| AEN04560.1 | dacZ | Halar_0789 | Halar_0747 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Protein of unknown function DUF147; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation. | 0.496 |
| AEN04560.1 | dphB | Halar_0789 | Halar_0827 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.900 |
| AEN04560.1 | fusA | Halar_0789 | Halar_0928 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.929 |
| AEN04560.1 | hisC | Halar_0789 | Halar_3537 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | PFAM: Aminotransferase, class I/II; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: hvo:HVO_1295 histidinol-phosphate aminotransferase. | 0.465 |
| AEN04560.1 | mptA | Halar_0789 | Halar_1782 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Protein of unknown function DUF198; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. | 0.485 |
| AEN04560.1 | nadK | Halar_0789 | Halar_1825 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.553 |
| AEN04560.1 | rpl19e | Halar_0789 | Halar_2463 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. | 0.471 |
| AEN04561.1 | AEN04560.1 | Halar_0790 | Halar_0789 | PFAM: Phosphoadenosine phosphosulphate reductase; KEGG: hvo:HVO_1079 sulfate adenylyltransferase small subunit. | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | 0.552 |
| AEN07106.1 | AEN04560.1 | Halar_3512 | Halar_0789 | PFAM: Asparagine synthase; KEGG: hbo:Hbor_22320 asparagine synthase (glutamine-hydrolyzing). | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | 0.725 |
