Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
AEN04587.1KEGG: hvo:HVO_1107 hypothetical protein; PFAM: Protein of unknown function DUF1119, archaea; SMART: Peptidase A22, presenilin signal peptide. (324 aa)    
Predicted Functional Partners:
AEN04588.1
KEGG: hbo:Hbor_22960 snornp protein gar1.
       0.875
srp19
Signal recognition particle 19 kDa protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
       0.875
topA
DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superc [...]
 
     0.825
AEN04657.1
PFAM: Protein of unknown function DUF1621; KEGG: hvo:HVO_0392 hypothetical protein.
  
     0.754
AEN06273.1
PRC-barrel domain protein; PFAM: PRC-barrel; KEGG: hvo:HVO_1691 putative PRC-barrel domain-containing protein.
  
     0.754
AEN06577.1
TIGRFAM: Peptidase S26B, eukaryotic signal peptidase; KEGG: hvo:HVO_0002 signal peptidase I.
  
     0.749
AEN07060.1
PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: hbo:Hbor_28820 hypothetical protein.
  
     0.725
AEN07059.1
PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: hvo:HVO_0292 replication protein A.
  
     0.722
AEN05190.1
KEGG: hla:Hlac_0624 hypothetical protein.
  
     0.714
AEN06410.1
PRC-barrel domain protein; PFAM: PRC-barrel; KEGG: hvo:HVO_1964 PRC-barrel domain-containing protein.
  
     0.711
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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