Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN04593.1PFAM: Protein of unknown function Met10; KEGG: hvo:HVO_0929 putative methyltransferase. (340 aa)    
Predicted Functional Partners:
AEN06246.1
Histone acetyltransferase, ELP3 family; SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: Histone acetyltransferase ELP3; KEGG: hla:Hlac_1480 histone acetyltransferase, ELP3 family; PFAM: Radical SAM; GCN5-related N-acetyltransferase.
 
  
 0.784
dphB
Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
 
  
 0.736
AEN06513.1
KH domain protein; KEGG: hbo:Hbor_00890 universal archaeal kh domain protein; TIGRFAM: KH domain protein, archaea; SMART: K Homology.
 
    0.669
rpl22
Ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
  
     0.653
ef1b
Elongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
  
   
 0.648
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
 
     0.628
AEN04591.1
ABC-type transporter, integral membrane subunit; PFAM: Bacterial transport system permease protein; KEGG: hma:rrnAC3374 corrinoid ABC transporter permease.
       0.627
AEN04592.1
Iron-chelate-transporting ATPase; PFAM: ABC transporter-like; KEGG: hbo:Hbor_23000 ABC cobalamin/Fe3+-siderophore transporter, ATPase component; SMART: ATPase, AAA+ type, core.
       0.625
trm1
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
  
  
 0.622
rpl4
50S ribosomal protein L4P; Forms part of the polypeptide exit tunnel.
  
    0.619
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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