| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEN04507.1 | AEN04560.1 | Halar_0736 | Halar_0789 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | 0.816 |
| AEN04507.1 | AEN04593.1 | Halar_0736 | Halar_0823 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: Protein of unknown function Met10; KEGG: hvo:HVO_0929 putative methyltransferase. | 0.406 |
| AEN04507.1 | AEN04606.1 | Halar_0736 | Halar_0838 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | KEGG: hla:Hlac_0782 small GTP-binding protein; TIGRFAM: Small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; TGS. | 0.606 |
| AEN04507.1 | AEN06151.1 | Halar_0736 | Halar_2497 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | PFAM: Pre-mRNA processing ribonucleoprotein, binding region; KEGG: hvo:HVO_1670 nucleolar protein-like protein. | 0.573 |
| AEN04507.1 | AEN06246.1 | Halar_0736 | Halar_2595 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Histone acetyltransferase, ELP3 family; SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: Histone acetyltransferase ELP3; KEGG: hla:Hlac_1480 histone acetyltransferase, ELP3 family; PFAM: Radical SAM; GCN5-related N-acetyltransferase. | 0.592 |
| AEN04507.1 | dphB | Halar_0736 | Halar_0827 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.953 |
| AEN04507.1 | fusA | Halar_0736 | Halar_0928 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.984 |
| AEN04507.1 | pelA | Halar_0736 | Halar_2599 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Pelota-like protein; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. | 0.591 |
| AEN04507.1 | psmA-2 | Halar_0736 | Halar_1652 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.549 |
| AEN04507.1 | rps4e | Halar_0736 | Halar_2469 | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | KEGG: hvo:HVO_2552 30S ribosomal protein S4.eR; HAMAP: 30S ribosomal protein S4e; PFAM: Ribosomal protein S4e, central; Ribosomal protein S4e, N-terminal; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.627 |
| AEN04560.1 | AEN04507.1 | Halar_0789 | Halar_0736 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.816 |
| AEN04560.1 | dphB | Halar_0789 | Halar_0827 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.900 |
| AEN04560.1 | fusA | Halar_0789 | Halar_0928 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] | 0.929 |
| AEN04560.1 | psmA-2 | Halar_0789 | Halar_1652 | KEGG: hla:Hlac_0801 ATP binding protein; TIGRFAM: universal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter protein; Protein of unknown function DUF71, ATP-binding region; PFAM: Protein of unknown function DUF71, ATP-binding region. | Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.445 |
| AEN04593.1 | AEN04507.1 | Halar_0823 | Halar_0736 | PFAM: Protein of unknown function Met10; KEGG: hvo:HVO_0929 putative methyltransferase. | Universal diphthamide biosynthesis domain-containing protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.406 |
| AEN04593.1 | AEN06151.1 | Halar_0823 | Halar_2497 | PFAM: Protein of unknown function Met10; KEGG: hvo:HVO_0929 putative methyltransferase. | PFAM: Pre-mRNA processing ribonucleoprotein, binding region; KEGG: hvo:HVO_1670 nucleolar protein-like protein. | 0.558 |
| AEN04593.1 | AEN06246.1 | Halar_0823 | Halar_2595 | PFAM: Protein of unknown function Met10; KEGG: hvo:HVO_0929 putative methyltransferase. | Histone acetyltransferase, ELP3 family; SMART: Elongator protein 3/MiaB/NifB; TIGRFAM: Histone acetyltransferase ELP3; KEGG: hla:Hlac_1480 histone acetyltransferase, ELP3 family; PFAM: Radical SAM; GCN5-related N-acetyltransferase. | 0.784 |
| AEN04593.1 | dphB | Halar_0823 | Halar_0827 | PFAM: Protein of unknown function Met10; KEGG: hvo:HVO_0929 putative methyltransferase. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.736 |
| AEN04593.1 | pelA | Halar_0823 | Halar_2599 | PFAM: Protein of unknown function Met10; KEGG: hvo:HVO_0929 putative methyltransferase. | Pelota-like protein; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. | 0.526 |
| AEN04593.1 | psmA-2 | Halar_0823 | Halar_1652 | PFAM: Protein of unknown function Met10; KEGG: hvo:HVO_0929 putative methyltransferase. | Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.588 |
