Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
AEN04627.1KEGG: hmu:Hmuk_2828 signal peptide peptidase SppA, 36K type; TIGRFAM: Peptidase S49, SppA; PFAM: Peptidase S49. (334 aa)    
Predicted Functional Partners:
AEN04626.1
PFAM: Protein of unknown function DUF373; KEGG: hvo:HVO_0882 hypothetical protein.
       0.778
AEN04628.1
KEGG: hla:Hlac_0452 hypothetical protein.
       0.720
AEN06344.1
Peptidase M50; KEGG: hwa:HQ1095A metalloprotease/metallo peptidase; PFAM: Peptidase M50; PDZ/DHR/GLGF; SMART: PDZ/DHR/GLGF.
     
 0.606
secD
Preprotein translocase subunit SecD; Involved in protein export.
 
   
 0.558
AEN07252.1
Rhomboid family protein; PFAM: Peptidase S54, rhomboid; Zinc finger, AN1-type; KEGG: hwa:HQ1233A rhomboid family protein/GlpG-like protein.
  
  
 0.534
ftsY
Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
 
   
 0.503
AEN07228.1
KEGG: hmu:Hmuk_3069 RDD domain containing protein; manually curated; PFAM: RDD.
 
  
 0.464
hisS
PFAM: Aminoacyl-tRNA synthetase, class II (G/ H/ P/ S), conserved region; Anticodon-binding; TIGRFAM: Histidyl-tRNA synthetase, class IIa, subgroup; HAMAP: Histidyl-tRNA synthetase, class IIa, subgroup; KEGG: hmu:Hmuk_1302 histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
     0.439
tatC-2
Sec-independent periplasmic protein translocase; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes.
 
  
 0.403
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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