Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN04653.1PHP domain protein; KEGG: hvo:HVO_0741 DNA polymerase X; PFAM: PHP, C-terminal; Helix-hairpin-helix motif; SMART: Polymerase/histidinol phosphatase, N-terminal; DNA-directed DNA polymerase, family X; Helix-hairpin-helix DNA-binding motif, class 1. (590 aa)    
Predicted Functional Partners:
lig
DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
 
 0.944
AEN04654.1
KEGG: hmu:Hmuk_2985 hypothetical protein.
       0.887
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
   
 0.847
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
    
 0.718
AEN07252.1
Rhomboid family protein; PFAM: Peptidase S54, rhomboid; Zinc finger, AN1-type; KEGG: hwa:HQ1233A rhomboid family protein/GlpG-like protein.
  
    0.620
radA
DNA repair and recombination protein radA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
    
 
 0.557
rad50
DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex. Belongs to the SMC family. RAD50 subfamily.
    
 
 0.540
AEN05598.1
PFAM: DNA-directed DNA polymerase, family B, conserved region; KEGG: hje:HacjB3_16936 DNA polymerase I.
 
 0.529
AEN05627.1
PFAM: RNA-metabolising metallo-beta-lactamase; KEGG: hma:rrnAC2133 mRNA 3'-end processing factor.
  
 
 0.527
hjc
Resolvase, Holliday junction-type; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family.
      
 0.510
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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