Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEN04670.1PilT protein domain protein; KEGG: hvo:HVO_0421 P-loop ATPase of the PilT family; PFAM: PilT protein, N-terminal; K Homology, type 1, subgroup; SMART: Nucleotide binding protein, PINc; ATPase, AAA+ type, core. (621 aa)    
Predicted Functional Partners:
AEN04671.1
PFAM: Peptidase M20; Peptidase M20, dimerisation; KEGG: hla:Hlac_0829 peptidase M20.
       0.813
AEN06489.1
Peptidase A24B, FlaK domain protein; PFAM: Peptidase A24B, preflagellin, C-terminal; Peptidase A24A, prepilin type IV; KEGG: hla:Hlac_2136 peptidase A24A prepilin type IV.
 
   
 0.715
tfe
Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...]
  
     0.649
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
 
     0.645
ef1b
Elongation factor 1-beta; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
 
     0.644
AEN05139.1
KEGG: hla:Hlac_1032 type II secretion system protein E; manually curated; PFAM: Type II secretion system protein E.
  
   
 0.600
trpS
Tryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp).
 
     0.545
AEN06018.1
PFAM: Type II secretion system protein E; KEGG: hvo:HVO_1160 type IV pilus biogenesis complex ATPase subunit.
 
   
 0.539
AEN04629.1
PFAM: Protein of unknown function DUF371; KEGG: hbo:Hbor_23420 hypothetical protein.
  
     0.537
cca
CCA-adding enzyme; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
  
   
 0.536
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.