Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN04691.1KEGG: hje:HacjB3_15185 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal. (320 aa)    
Predicted Functional Partners:
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
 
 0.994
AEN06902.1
KEGG: hvo:HVO_0008 aspartokinase; TIGRFAM: Aspartate kinase region; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Belongs to the aspartokinase family.
 
 0.989
AEN05518.1
TIGRFAM: Aspartate-semialdehyde dehydrogenase, peptidoglycan lacking; KEGG: hvo:HVO_2487 aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, dimerisation region; Semialdehyde dehydrogenase, NAD-binding.
 
 0.982
metXA
Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
 
 0.966
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
 
 0.934
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.917
AEN05455.1
Acetylornithine transaminase; KEGG: hla:Hlac_1048 aminotransferase class-III; PFAM: Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
    
 0.908
AEN04692.1
PFAM: Amino acid-binding ACT; KEGG: nmg:Nmag_2514 amino acid-binding ACT domain protein.
       0.907
AEN05241.1
Cysteine synthase; KEGG: hbo:Hbor_02440 oah/oas sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme.
 
 
 0.907
AEN05061.1
D-amino-acid transaminase; KEGG: hbo:Hbor_25080 branched chain amino acid aminotransferase apoenzyme; PFAM: Aminotransferase, class IV; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.904
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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