Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN04751.1Transcriptional regulator, XRE family; KEGG: hbo:Hbor_25480 hypothetical protein; PFAM: Phosphomethylpyrimidine kinase; Helix-turn-helix type 3; SMART: Helix-turn-helix type 3. (312 aa)    
Predicted Functional Partners:
dcd
Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP.
       0.863
fau-1
RNA-binding protein AU-1; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.
  
     0.677
AEN04629.1
PFAM: Protein of unknown function DUF371; KEGG: hbo:Hbor_23420 hypothetical protein.
  
     0.604
AEN04750.1
KEGG: hwa:HQ1275A glutathione S-transferase; PFAM: Glutathione S-transferase, C-terminal.
       0.586
AEN06531.1
PFAM: Methyltransferase type 11; KEGG: hla:Hlac_1585 methyltransferase type 11.
       0.581
pfdB
Prefoldin subunit beta; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
  
     0.560
AEN04650.1
Protein of unknown function DUF650; Involved in DNA damage repair.
  
     0.501
AEN05939.1
KEGG: hla:Hlac_2163 hypothetical protein.
 
     0.497
AEN05073.1
KEGG: hsl:OE1577R hypothetical protein.
  
     0.489
tfe
Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...]
  
     0.488
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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