Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN04761.1PFAM: Protein of unknown function DUF2144; KEGG: hla:Hlac_0566 rpo operon protein. (86 aa)    
Predicted Functional Partners:
rpoP
DNA-directed RNA polymerase subunit P; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family.
  
    0.979
AEN06365.1
O-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / TsaD family.
    
 0.974
rpl37ae
Ribosomal L37ae protein; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL43 family.
       0.907
AEN06895.1
KEGG: hvo:HVO_0013 putative KEOPS complex component.
     
 0.860
pfdB
Prefoldin subunit beta; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
  
    0.647
AEN06702.1
KEGG: hbo:Hbor_25590 hypothetical protein.
       0.611
AEN04762.1
KEGG: hbo:Hbor_28400 L-proline dehydrogenase; PFAM: Proline dehydrogenase.
       0.535
AEN04758.1
PFAM: Protein of unknown function DUF2103, metal-binding; KEGG: hvo:HVO_0656 hypothetical protein.
       0.459
AEN04763.1
PFAM: Protein of unknown function DUF502; KEGG: hut:Huta_2020 protein of unknown function DUF502.
       0.435
psmA
Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
       0.424
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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