Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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AEN04767.1ERCC4 domain protein; KEGG: hbo:Hbor_02260 ERCC4-like helicase; PFAM: ERCC4 domain; DNA/RNA helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helix-hairpin-helix motif; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; Helix-hairpin-helix DNA-binding motif, class 1. (790 aa)    
Predicted Functional Partners:
rpl1
Ribosomal protein L1; Binds directly to 23S rRNA. Probably involved in E site tRNA release.
    
 0.851
AEN07074.1
PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: hbo:Hbor_26830 single-stranded DNA-binding protein.
 
 
 0.841
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
  
 
 
 0.827
uvrC
UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
      
 0.766
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 
 0.742
rpl40e
KEGG: hut:Huta_1320 50S ribosomal protein L40e; HAMAP: 50S ribosomal protein L40e; PFAM: Ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 
  0.726
AEN07059.1
PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: hvo:HVO_0292 replication protein A.
 
 
 0.711
AEN05056.1
KEGG: nph:NP1508A family B DNA-directed DNA polymerase; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; Hedgehog/intein hint, N-terminal.
 
 
 
 0.684
AEN05189.1
PFAM: Nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: hla:Hlac_0623 replication factor A.
 
 
 0.676
AEN07262.1
PFAM: DNA helicase, UvrD/REP type; KEGG: hla:Hlac_0203 UvrD/REP helicase.
    
 
 0.670
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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