Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN04776.1SMART: Helicase, ATP-dependent, c2 type; KEGG: hvo:HVO_0099 hypothetical protein. (615 aa)    
Predicted Functional Partners:
tfe
Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...]
  
 0.844
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
 
 0.810
AEN06968.1
KEGG: hbo:Hbor_01240 hypothetical protein.
       0.730
rad25
Type III restriction protein res subunit; KEGG: hbo:Hbor_14720 DNA/RNA helicase, superfamily II; PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; DNA/RNA helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal.
  
 0.724
AEN05287.1
PFAM: DNA-directed RNA polymerase, insert; DNA-directed RNA polymerase, dimerisation; KEGG: hla:Hlac_1819 RNA polymerase insert; SMART: DNA-directed RNA polymerase, RpoA/D/Rpb3-type.
  
 0.711
AEN05309.1
Type III restriction protein res subunit; KEGG: hbo:Hbor_16170 DNA repair helicase rad25; PFAM: Restriction endonuclease, type I, R subunit/Type III, Res subunit; DNA/RNA helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal.
   
 0.707
AEN07262.1
PFAM: DNA helicase, UvrD/REP type; KEGG: hla:Hlac_0203 UvrD/REP helicase.
 
 
 0.706
AEN05056.1
KEGG: nph:NP1508A family B DNA-directed DNA polymerase; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; Hedgehog/intein hint, N-terminal.
 
 0.705
AEN05939.1
KEGG: hla:Hlac_2163 hypothetical protein.
  
     0.692
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
    
 0.686
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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