| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEN04961.1 | AEN04962.1 | Halar_1209 | Halar_1210 | KEGG: hvo:HVO_A0489 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Formyl-CoA transferase; KEGG: hvo:HVO_A0490 CaiB/BaiF family protein; PFAM: CoA-transferase family III. | 0.835 |
| AEN04961.1 | AEN05061.1 | Halar_1209 | Halar_1315 | KEGG: hvo:HVO_A0489 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | D-amino-acid transaminase; KEGG: hbo:Hbor_25080 branched chain amino acid aminotransferase apoenzyme; PFAM: Aminotransferase, class IV; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.887 |
| AEN04961.1 | AEN05158.1 | Halar_1209 | Halar_1419 | KEGG: hvo:HVO_A0489 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | KEGG: nph:NP2192A 3-isopropylmalate dehydratase, small subunit; TIGRFAM: 3-isopropylmalate dehydratase, small subunit region; PFAM: Aconitase A/isopropylmalate dehydratase small subunit, swivel. | 0.976 |
| AEN04961.1 | AEN05159.1 | Halar_1209 | Halar_1420 | KEGG: hvo:HVO_A0489 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | KEGG: nph:NP2194A isopropylmalate isomerase large subunit; TIGRFAM: 3-isopropylmalate dehydratase, large subunit region; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha. | 0.974 |
| AEN04961.1 | AEN05162.1 | Halar_1209 | Halar_1423 | KEGG: hvo:HVO_A0489 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | KEGG: hje:HacjB3_10545 acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. | 0.931 |
| AEN04961.1 | AEN05163.1 | Halar_1209 | Halar_1424 | KEGG: hvo:HVO_A0489 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: hma:rrnAC0330 acetolactate synthase large subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region. | 0.819 |
| AEN04961.1 | AEN05845.1 | Halar_1209 | Halar_2164 | KEGG: hvo:HVO_A0489 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | KEGG: hje:HacjB3_10520 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. | 0.971 |
| AEN04961.1 | ilvC | Halar_1209 | Halar_1422 | KEGG: hvo:HVO_A0489 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.860 |
| AEN04961.1 | ilvD | Halar_1209 | Halar_1426 | KEGG: hvo:HVO_A0489 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: hvo:HVO_2646 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.816 |
| AEN04961.1 | ilvE | Halar_1209 | Halar_2889 | KEGG: hvo:HVO_A0489 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.918 |
| AEN04962.1 | AEN04961.1 | Halar_1210 | Halar_1209 | Formyl-CoA transferase; KEGG: hvo:HVO_A0490 CaiB/BaiF family protein; PFAM: CoA-transferase family III. | KEGG: hvo:HVO_A0489 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.835 |
| AEN04962.1 | AEN05163.1 | Halar_1210 | Halar_1424 | Formyl-CoA transferase; KEGG: hvo:HVO_A0490 CaiB/BaiF family protein; PFAM: CoA-transferase family III. | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: hma:rrnAC0330 acetolactate synthase large subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region. | 0.408 |
| AEN05061.1 | AEN04961.1 | Halar_1315 | Halar_1209 | D-amino-acid transaminase; KEGG: hbo:Hbor_25080 branched chain amino acid aminotransferase apoenzyme; PFAM: Aminotransferase, class IV; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | KEGG: hvo:HVO_A0489 homocitrate synthase; PFAM: Pyruvate carboxyltransferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.887 |
| AEN05061.1 | AEN05159.1 | Halar_1315 | Halar_1420 | D-amino-acid transaminase; KEGG: hbo:Hbor_25080 branched chain amino acid aminotransferase apoenzyme; PFAM: Aminotransferase, class IV; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | KEGG: nph:NP2194A isopropylmalate isomerase large subunit; TIGRFAM: 3-isopropylmalate dehydratase, large subunit region; PFAM: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha. | 0.669 |
| AEN05061.1 | AEN05162.1 | Halar_1315 | Halar_1423 | D-amino-acid transaminase; KEGG: hbo:Hbor_25080 branched chain amino acid aminotransferase apoenzyme; PFAM: Aminotransferase, class IV; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | KEGG: hje:HacjB3_10545 acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT. | 0.696 |
| AEN05061.1 | AEN05163.1 | Halar_1315 | Halar_1424 | D-amino-acid transaminase; KEGG: hbo:Hbor_25080 branched chain amino acid aminotransferase apoenzyme; PFAM: Aminotransferase, class IV; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | TIGRFAM: Acetolactate synthase, large subunit, biosynthetic; KEGG: hma:rrnAC0330 acetolactate synthase large subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, N-terminal TPP binding region; Thiamine pyrophosphate enzyme, central region. | 0.543 |
| AEN05061.1 | AEN05845.1 | Halar_1315 | Halar_2164 | D-amino-acid transaminase; KEGG: hbo:Hbor_25080 branched chain amino acid aminotransferase apoenzyme; PFAM: Aminotransferase, class IV; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | KEGG: hje:HacjB3_10520 3-isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase. | 0.450 |
| AEN05061.1 | ilvC | Halar_1315 | Halar_1422 | D-amino-acid transaminase; KEGG: hbo:Hbor_25080 branched chain amino acid aminotransferase apoenzyme; PFAM: Aminotransferase, class IV; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.426 |
| AEN05061.1 | ilvD | Halar_1315 | Halar_1426 | D-amino-acid transaminase; KEGG: hbo:Hbor_25080 branched chain amino acid aminotransferase apoenzyme; PFAM: Aminotransferase, class IV; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; HAMAP: Dihydroxy-acid dehydratase; KEGG: hvo:HVO_2646 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.973 |
| AEN05061.1 | ilvE | Halar_1315 | Halar_2889 | D-amino-acid transaminase; KEGG: hbo:Hbor_25080 branched chain amino acid aminotransferase apoenzyme; PFAM: Aminotransferase, class IV; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.914 |