Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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panProteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] (404 aa)    
Predicted Functional Partners:
AEN06328.1
SMART: ATPase, AAA+ type, core; TIGRFAM: 26S proteasome subunit P45; KEGG: hbo:Hbor_05530 proteasome-activating nucleotidase; PFAM: ATPase, AAA-type, core; Belongs to the AAA ATPase family.
  
  
 
0.993
glpK
Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
  
 0.913
AEN06377.1
KEGG: hla:Hlac_1958 AAA ATPase central domain protein; PFAM: ATPase, AAA-type, core; SMART: ATPase, AAA+ type, core; Belongs to the AAA ATPase family.
 
 
0.911
AEN04510.1
PFAM: Peptidase S1/S6, chymotrypsin/Hap; KEGG: hma:rrnAC0296 serine protease HtrA.
   
 0.892
psmA
Proteasome endopeptidase complex, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 0.877
psmB
Proteasome endopeptidase complex, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.857
AEN04927.1
Mov34/MPN/PAD-1 family protein; PFAM: Mov34/MPN/PAD-1; KEGG: hbo:Hbor_21950 proteasome rpn11 subunit jamm motif protein.
  
 0.836
AEN05625.1
KEGG: hla:Hlac_1268 Mov34/MPN/PAD-1 family protein; PFAM: Mov34/MPN/PAD-1; SMART: Mov34/MPN/PAD-1.
  
 0.836
rad50
DNA double-strand break repair rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex. Belongs to the SMC family. RAD50 subfamily.
   
 
 0.804
psmA-2
Proteasome endopeptidase complex; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 0.784
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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