Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (337 aa)    
Predicted Functional Partners:
AEN05133.1
PFAM: GHMP kinase; GHMP kinase, C-terminal; KEGG: hla:Hlac_1434 GHMP kinase.
 
 
 0.996
AEN06468.1
TIGRFAM: Hydroxymethylglutaryl-CoA reductase, class I, catalytic; KEGG: hvo:HVO_2583 hydroxymethylglutaryl-CoA reductase (NADPH); PFAM: Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic; Belongs to the HMG-CoA reductase family.
 
 0.980
AEN05278.1
Aspartate/glutamate/uridylate kinase; Catalyzes the phosphorylation of isopentenyl phosphate (IP) to isopentenyl diphosphate (IPP). Functions in an alternate mevalonate (MVA) pathway leading to IPP, a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
 
   
 0.955
AEN07279.1
KEGG: hbo:Hbor_08530 hydroxymethylglutaryl-CoA synthase; PFAM: Hydroxymethylglutaryl-coenzyme A synthase, N-terminal; Hydroxymethylglutaryl-coenzyme A synthase C-terminal.
 
  
 0.846
AEN05294.1
ATPase-like, ParA/MinD; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
       0.765
AEN07149.1
PFAM: Protein of unknown function DUF35; KEGG: nph:NP2608A hydroxymethylglutaryl-CoA synthase 1.
 
  
 0.712
AEN05539.1
KEGG: hbo:Hbor_12180 cystathionine gamma-lyase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme.
 
      0.698
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
     
 0.680
AEN06829.1
KEGG: hsl:OE2173F cystathionine synthase/lyase (cystathionine gamma-synthase, cystathionine gamma-lyase, cystathionine beta-lyase); PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme.
 
      0.679
rps2
Ribosomal protein S2; KEGG: hbo:Hbor_12460 SSU ribosomal protein s2p; TIGRFAM: Ribosomal protein S2, eukaryotic/archaeal; PFAM: Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.
       0.644
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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