Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
queCexsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (244 aa)    
Predicted Functional Partners:
queE
Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
 
 0.999
AEN05355.1
Queuosine biosynthesis protein QueD; KEGG: htu:Htur_1391 6-pyruvoyl-tetrahydropterin synthase-like protein; TIGRFAM: queuosine biosynthesis protein QueD; PFAM: 6-pyruvoyl tetrahydropterin synthase-related.
 
  
 0.991
AEN05828.1
Manually curated; KEGG: hut:Huta_2000 6-pyruvoyltetrahydropterin synthase.
 
  
 0.902
AEN05354.1
Hypothetical protein.
       0.541
tmk
PFAM: Thymidylate kinase-like; TIGRFAM: Thymidylate kinase; HAMAP: Thymidylate kinase; KEGG: hvo:HVO_2207 thymidylate kinase.
  
   
 0.502
tgtA
7-cyano-7-deazaguanine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.
 
   
 0.466
dcd
Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP.
     
 0.433
AEN06554.1
PFAM: Dihydroorotate dehydrogenase, class 1/ 2; TIGRFAM: Dihydroorotate dehydrogenase, class 2; HAMAP: Dihydroorotate dehydrogenase; KEGG: hla:Hlac_0019 dihydroorotate dehydrogenase 2.
       0.424
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.