STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEN05417.1Winged helix-turn-helix transcription repressor, HrcA DNA-binding domain protein; PFAM: Protein of unknown function DUF293, archaea; KEGG: hbo:Hbor_16490 transcriptional regulator, contains C-terminal cbs domains. (177 aa)    
Predicted Functional Partners:
AEN05418.1
PFAM: NAD-dependent epimerase/dehydratase; KEGG: hbo:Hbor_31640 nucleoside-diphosphate-sugar epimerase.
       0.829
AEN06574.1
PFAM: Uncharacterised conserved protein UCP004977; KEGG: nmg:Nmag_1928 hypothetical protein.
  
     0.724
cofC
2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.
  
     0.722
rnp3
Ribonuclease P protein component 3; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
  
     0.693
AEN05229.1
Protein of unknown function UPF0058; PFAM: Uncharacterised protein family UPF0058; KEGG: nmg:Nmag_3221 protein of unknown function UPF0058.
  
     0.689
AEN07221.1
Transcriptional regulator, MarR family; KEGG: hbo:Hbor_24020 transcriptional regulator; PFAM: HTH transcriptional regulator, MarR; SMART: HTH transcriptional regulator, Crp.
  
     0.677
AEN04692.1
PFAM: Amino acid-binding ACT; KEGG: nmg:Nmag_2514 amino acid-binding ACT domain protein.
  
     0.673
tfe
Transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems [...]
  
     0.666
AEN06602.1
PFAM: Protein of unknown function DUF460; KEGG: hbo:Hbor_29620 hypothetical protein.
  
     0.661
AEN04926.1
PFAM: Phosphoesterase, RecJ-like; Nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: hvo:HVO_1018 hypothetical protein.
  
     0.651
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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