Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cofDLPPG:FO 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (359 aa)    
Predicted Functional Partners:
cofE
F420-0:gamma-glutamyl ligase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
 
 
 0.994
cofC
2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.
 
  
 0.980
cofG
FO synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
 
  
 0.979
AEN05484.1
KEGG: htu:Htur_1893 tRNA-dihydrouridine synthase-like protein.
 
     0.925
AEN05483.1
PFAM: Triphosphoribosyl-dephospho-CoA protein; KEGG: hla:Hlac_2336 triphosphoribosyl-dephospho-CoA protein.
 
     0.921
AEN05482.1
PFAM: Protein of unknown function DUF447; KEGG: hvo:HVO_2476 hypothetical protein.
       0.907
AEN05905.1
PFAM: Radical SAM; KEGG: hla:Hlac_2018 FO synthase subunit 2.
 
  
 0.905
AEN06920.1
KEGG: hvo:HVO_0433 NADPH-dependent F420 reductase; TIGRFAM: NADPH-dependent F420 reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent.
 
   
 0.771
AEN05359.1
KEGG: hma:rrnAC0239 N5N10-methylenetetrahydromethanopterin reductase; PFAM: Luciferase-like, subgroup.
 
   
 0.762
mer
5,10-methylenetetrahydromethanopterin reductase; Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT.
 
   
 0.735
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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