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[Homology]
Score
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (429 aa)    
Predicted Functional Partners:
hisB
HAMAP: Imidazoleglycerol-phosphate dehydratase; KEGG: hla:Hlac_2701 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase.
  
 0.998
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.995
hisC
PFAM: Aminotransferase, class I/II; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: hvo:HVO_1295 histidinol-phosphate aminotransferase.
  
 0.993
hisA
1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis; TIGRFAM: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; HAMAP: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: hla:Hlac_2699 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase.
  
 0.992
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.983
hisH-2
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
 0.982
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.955
hisE
TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphatase; KEGG: nph:NP0470A phosphoribosyl-ATP pyrophosphatase; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase.
 
  
 0.945
AEN06765.1
PFAM: Aminotransferase, class I/II; KEGG: hmu:Hmuk_0141 L-threonine-O-3-phosphate decarboxylase.
 
  
 0.906
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
  
 0.821
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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