Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rtcBProtein of unknown function UPF0027; PFAM: Uncharacterised protein family UPF0027; KEGG: hvo:HVO_2712 RNA terminal phosphate cyclase operon orfB-like protein; Belongs to the RtcB family. (485 aa)    
Predicted Functional Partners:
AEN05496.1
Protein of unknown function DUF101; PFAM: Archease, tRNA m5C methyltransferase chaperone; KEGG: hut:Huta_2756 protein of unknown function DUF101.
 
 0.993
flpA
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family.
   
 0.916
AEN06902.1
KEGG: hvo:HVO_0008 aspartokinase; TIGRFAM: Aspartate kinase region; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Belongs to the aspartokinase family.
     
 0.784
AEN05527.1
DoxX family protein; PFAM: DoxX; KEGG: hbo:Hbor_11740 DoxX protein.
       0.752
rnz
Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.
 
   
 0.599
endA
tRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
     
 0.581
dtdA
D-tyrosyl-tRNA(Tyr) deacylase; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
     
 0.574
AEN05369.1
KEGG: hvo:HVO_1477 endonuclease; PFAM: Staphylococcal nuclease (SNase-like); SMART: Staphylococcal nuclease (SNase-like).
     
 0.560
AEN05968.1
Manually curated; PFAM: Staphylococcal nuclease (SNase-like); Excalibur calcium-binding domain; KEGG: hje:HacjB3_11930 nuclease (SNase domain protein); SMART: Staphylococcal nuclease (SNase-like).
     
 0.508
prf1
Peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
  
  
 0.504
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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