Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN05846.1Cobalamin-independent synthase MetE domain protein; PFAM: Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal; KEGG: hvo:HVO_2743 methionine synthase vitamin-B12 independent. (335 aa)    
Predicted Functional Partners:
metE
Methylcobalamin:homocysteine methyltransferase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown.
 
  
 
0.992
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
 
 
 0.963
AEN06829.1
KEGG: hsl:OE2173F cystathionine synthase/lyase (cystathionine gamma-synthase, cystathionine gamma-lyase, cystathionine beta-lyase); PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme.
  
 
 0.941
AEN05241.1
Cysteine synthase; KEGG: hbo:Hbor_02440 oah/oas sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme.
  
 
 0.929
AEN05978.1
Cysteine synthase; KEGG: hla:Hlac_1763 pyridoxal-5'-phosphate-dependent protein beta subunit; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit.
  
 
 0.914
metG
Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
    
 0.912
AEN06158.1
KEGG: hmu:Hmuk_2306 methionine adenosyltransferase; PFAM: S-adenosylmethionine synthetase (MAT), archaea.
     
  0.900
mat
S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family.
     
  0.900
AEN04691.1
KEGG: hje:HacjB3_15185 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal.
  
 
 0.879
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
 
 
 0.856
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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