Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
AEN05864.15'-Nucleotidase domain-containing protein; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; KEGG: hbo:Hbor_11400 5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase. (464 aa)    
Predicted Functional Partners:
tmk
PFAM: Thymidylate kinase-like; TIGRFAM: Thymidylate kinase; HAMAP: Thymidylate kinase; KEGG: hvo:HVO_2207 thymidylate kinase.
  
 
 0.947
udk
TIGRFAM: Uridine kinase; HAMAP: Uridine kinase; KEGG: hla:Hlac_1557 uridine kinase; PFAM: Phosphoribulokinase/uridine kinase.
 
 
 0.930
AEN06059.1
Phosphoribosyltransferase; May catalyze a purine salvage reaction, the substrate is unknown.
 
  
 0.926
AEN05315.1
KEGG: hmu:Hmuk_2739 cytidine deaminase; TIGRFAM: Cytidine deaminase, homotetrameric; PFAM: CMP/dCMP deaminase, zinc-binding.
 
  
 0.924
tdk
HAMAP: Thymidine kinase, subgroup; KEGG: hvo:HVO_2891 thymidine kinase; PFAM: Thymidine kinase.
 
  
  0.923
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
   
 0.922
AEN04577.1
TIGRFAM: Adenylosuccinate lyase; KEGG: hbo:Hbor_22730 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 
 0.921
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
    
 0.918
AEN06363.1
Nucleoside-triphosphatase; KEGG: hbo:Hbor_04980 ditpase; PFAM: Ham1-like protein.
 
 
 0.918
AEN06301.1
PFAM: Metallophosphoesterase; KEGG: hmu:Hmuk_0118 metallophosphoesterase.
  
 
 0.916
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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