Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cofC2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (206 aa)    
Predicted Functional Partners:
cofD
LPPG:FO 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
 
  
 0.980
cofG
FO synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.
 
   
 0.974
cetZ-2
Tubulin/FtsZ GTPase; Involved in cell shape control; Belongs to the CetZ family.
 
   
 0.908
AEN05905.1
PFAM: Radical SAM; KEGG: hla:Hlac_2018 FO synthase subunit 2.
 
   
 0.847
AEN06448.1
Molybdenum cofactor synthesis domain protein; KEGG: hbo:Hbor_07200 molybdopterin molybdochelatase; TIGRFAM: Molybdenum cofactor synthesis; PFAM: MoeA, N-terminal region, domain I/II; Molybdopterin binding; MoeA, C-terminal, domain IV.
       0.779
cofE
F420-0:gamma-glutamyl ligase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
 
   
 0.777
AEN06574.1
PFAM: Uncharacterised conserved protein UCP004977; KEGG: nmg:Nmag_1928 hypothetical protein.
  
     0.731
AEN04692.1
PFAM: Amino acid-binding ACT; KEGG: nmg:Nmag_2514 amino acid-binding ACT domain protein.
  
     0.725
AEN05417.1
Winged helix-turn-helix transcription repressor, HrcA DNA-binding domain protein; PFAM: Protein of unknown function DUF293, archaea; KEGG: hbo:Hbor_16490 transcriptional regulator, contains C-terminal cbs domains.
  
     0.722
AEN05229.1
Protein of unknown function UPF0058; PFAM: Uncharacterised protein family UPF0058; KEGG: nmg:Nmag_3221 protein of unknown function UPF0058.
  
     0.710
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.