Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEN05955.1KEGG: hwa:HQ3584A hypothetical protein. (112 aa)    
Predicted Functional Partners:
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
   
 0.767
AEN07051.1
Transcriptional regulator, XRE family; KEGG: nph:NP5106A ATP-dependent DNA helicase (intein-containing); PFAM: DNA-dependent ATPase MCM; Helix-turn-helix type 3; SMART: DNA-dependent ATPase MCM; Hedgehog/intein hint, N-terminal; Helix-turn-helix type 3; Hedgehog/intein hint domain, C-terminal; Belongs to the MCM family.
   
 0.721
priL
DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
  
 0.716
AEN05759.1
KEGG: adn:Alide_4134 hypothetical protein.
    
 0.684
fen
Flap structure-specific endonuclease; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair [...]
   
 0.670
priS
DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]
   
 0.660
AEN05056.1
KEGG: nph:NP1508A family B DNA-directed DNA polymerase; PFAM: DNA-directed DNA polymerase, family B, conserved region; DNA-directed DNA polymerase, family B, exonuclease domain; SMART: DNA-directed DNA polymerase, family B; Hedgehog/intein hint, N-terminal.
   
 0.643
AEN05598.1
PFAM: DNA-directed DNA polymerase, family B, conserved region; KEGG: hje:HacjB3_16936 DNA polymerase I.
   
 0.625
AEN04767.1
ERCC4 domain protein; KEGG: hbo:Hbor_02260 ERCC4-like helicase; PFAM: ERCC4 domain; DNA/RNA helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helix-hairpin-helix motif; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; Helix-hairpin-helix DNA-binding motif, class 1.
   
 0.624
polB
DNA-directed DNA polymerase; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.
   
 0.617
Your Current Organism:
halophilic archaeon DL31
NCBI taxonomy Id: 756883
Other names: h. archaeon DL31
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