| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEN04576.1 | AEN04577.1 | Halar_0806 | Halar_0807 | Phosphoribosylglycinamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: Phosphoribosylglycinamide formyltransferase; KEGG: hla:Hlac_0925 phosphoribosylglycinamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; Formyl transferase, N-terminal. | TIGRFAM: Adenylosuccinate lyase; KEGG: hbo:Hbor_22730 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.998 |
| AEN04576.1 | AEN06059.1 | Halar_0806 | Halar_2401 | Phosphoribosylglycinamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: Phosphoribosylglycinamide formyltransferase; KEGG: hla:Hlac_0925 phosphoribosylglycinamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; Formyl transferase, N-terminal. | Phosphoribosyltransferase; May catalyze a purine salvage reaction, the substrate is unknown. | 0.960 |
| AEN04576.1 | hisF | Halar_0806 | Halar_2526 | Phosphoribosylglycinamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: Phosphoribosylglycinamide formyltransferase; KEGG: hla:Hlac_0925 phosphoribosylglycinamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; Formyl transferase, N-terminal. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.866 |
| AEN04576.1 | hisH | Halar_0806 | Halar_0955 | Phosphoribosylglycinamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: Phosphoribosylglycinamide formyltransferase; KEGG: hla:Hlac_0925 phosphoribosylglycinamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; Formyl transferase, N-terminal. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.845 |
| AEN04576.1 | hisH-2 | Halar_0806 | Halar_3150 | Phosphoribosylglycinamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: Phosphoribosylglycinamide formyltransferase; KEGG: hla:Hlac_0925 phosphoribosylglycinamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; Formyl transferase, N-terminal. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.845 |
| AEN04577.1 | AEN04576.1 | Halar_0807 | Halar_0806 | TIGRFAM: Adenylosuccinate lyase; KEGG: hbo:Hbor_22730 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylglycinamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, formylation region; TIGRFAM: Phosphoribosylglycinamide formyltransferase; KEGG: hla:Hlac_0925 phosphoribosylglycinamide formyltransferase; PFAM: AICARFT/IMPCHase bienzyme, formylation region; Formyl transferase, N-terminal. | 0.998 |
| AEN04577.1 | AEN05864.1 | Halar_0807 | Halar_2183 | TIGRFAM: Adenylosuccinate lyase; KEGG: hbo:Hbor_22730 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 5'-Nucleotidase domain-containing protein; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; KEGG: hbo:Hbor_11400 5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase. | 0.921 |
| AEN04577.1 | AEN06059.1 | Halar_0807 | Halar_2401 | TIGRFAM: Adenylosuccinate lyase; KEGG: hbo:Hbor_22730 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosyltransferase; May catalyze a purine salvage reaction, the substrate is unknown. | 0.962 |
| AEN04577.1 | AEN06301.1 | Halar_0807 | Halar_2652 | TIGRFAM: Adenylosuccinate lyase; KEGG: hbo:Hbor_22730 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | PFAM: Metallophosphoesterase; KEGG: hmu:Hmuk_0118 metallophosphoesterase. | 0.908 |
| AEN04577.1 | AEN07130.1 | Halar_0807 | Halar_3536 | TIGRFAM: Adenylosuccinate lyase; KEGG: hbo:Hbor_22730 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. | 0.900 |
| AEN04577.1 | adk | Halar_0807 | Halar_3659 | TIGRFAM: Adenylosuccinate lyase; KEGG: hbo:Hbor_22730 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.947 |
| AEN04577.1 | hisF | Halar_0807 | Halar_2526 | TIGRFAM: Adenylosuccinate lyase; KEGG: hbo:Hbor_22730 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.853 |
| AEN04577.1 | hisH | Halar_0807 | Halar_0955 | TIGRFAM: Adenylosuccinate lyase; KEGG: hbo:Hbor_22730 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.815 |
| AEN04577.1 | hisH-2 | Halar_0807 | Halar_3150 | TIGRFAM: Adenylosuccinate lyase; KEGG: hbo:Hbor_22730 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.815 |
| AEN04577.1 | surE | Halar_0807 | Halar_1494 | TIGRFAM: Adenylosuccinate lyase; KEGG: hbo:Hbor_22730 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.928 |
| AEN05864.1 | AEN04577.1 | Halar_2183 | Halar_0807 | 5'-Nucleotidase domain-containing protein; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; KEGG: hbo:Hbor_11400 5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase. | TIGRFAM: Adenylosuccinate lyase; KEGG: hbo:Hbor_22730 adenylosuccinate lyase; PFAM: Adenylosuccinate lyase C-terminal; Fumarate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.921 |
| AEN05864.1 | AEN06059.1 | Halar_2183 | Halar_2401 | 5'-Nucleotidase domain-containing protein; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; KEGG: hbo:Hbor_11400 5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase. | Phosphoribosyltransferase; May catalyze a purine salvage reaction, the substrate is unknown. | 0.926 |
| AEN05864.1 | AEN06301.1 | Halar_2183 | Halar_2652 | 5'-Nucleotidase domain-containing protein; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; KEGG: hbo:Hbor_11400 5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase. | PFAM: Metallophosphoesterase; KEGG: hmu:Hmuk_0118 metallophosphoesterase. | 0.916 |
| AEN05864.1 | AEN07130.1 | Halar_2183 | Halar_3536 | 5'-Nucleotidase domain-containing protein; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; KEGG: hbo:Hbor_11400 5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase. | Adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. | 0.912 |
| AEN05864.1 | adk | Halar_2183 | Halar_3659 | 5'-Nucleotidase domain-containing protein; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; KEGG: hbo:Hbor_11400 5'-nucleotidase/2',3'-cyclic phosphodiesterase-like hydrolase. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.906 |